Fig. 6
Chromatograms of [18F]PSMA-1007. a The typical radio-chromatogram of [18F]PSMA-1007 solution using cassettes with three types of tubing material. The radiochemical purity was 95% with each cassette with trifluoroacetic acid (TFA) salt precursor. For the acetic acid ACE salt precursor, the radiochemical purity was > 97%. b The typical UV-chromatogram of the PSMA-1007 reference standard and [18F]PSMA-1007 solution produced using cassettes with three types of tubing material with precursors. The PSMA-1007 reference standard was 5 μg/mL (retention time (RT) 8.192 min). The PSMA-1007 with the Fluoro-elastomer was 8.5 μg/mL (RT 8.211 min), whereas that obtained with the other tubing material was 0.3 μg/mL (RT 8.208 and 8.189 min). The highest single chemical impurity peak was detected at approximately 7.5 min of retention time and the impurity profiles of the chromatograms were similar. For the ACE salt precursor, the highest single chemical impurity peak was detected at a retention time of 8.9 min
PnarMed® BPT