Table 1 Binding affinity (Ki) of compounds 1–3 for 5-HT1A receptors and other biogenic amines, neurotransmitter receptors, and transporters
(1) | (2) | (3) | |
|---|---|---|---|
Target | Ki(nM) | Ki(nM) | Ki(nM) |
5-HT1A | 22 | 7.7 | 5.8 |
5-HT1B | > 10,000 | > 10,000 | > 10,000 |
5-HT1E | > 10,000 | > 10,000 | > 10,000 |
5-HT1D | > 10,000 | > 10,000 | 1176 |
5-HT2A | > 10,000 | > 10,000 | > 10,000 |
5-HT2B | 403 | 516 | 137 |
5-HT2C | > 10,000 | > 10,000 | > 10,000 |
5-HT3 | > 10,000 | > 10,000 | > 10,000 |
5-HT4 | > 10,000 | > 10,000 | > 10,000 |
5-HT5a | > 10,000 | > 10,000 | 1805 |
5-HT6 | > 10,000 | > 10,000 | > 10,000 |
5-HT7R | 76 | 830 | 530 |
Alpha1A | 129 | 46 | 23 |
Alpha1B | 1080 | 254 | 142 |
Alpha1D | 213 | 53 | 19 |
Alpha 2A | 453 | > 10,000 | > 10,000 |
Alpha2B | 670 | > 10,000 | 2215 |
Alpha2C | 835 | > 10,000 | 1984 |
D2R | 777 | > 10,000 | 800 |
D3R | 369 | 2552 | 133 |
D4R | 137 | 88 | 153 |
D1, D5 | > 10,000 | > 10,000 | > 10,000 |
DAT | > 10,000 | > 10,000 | > 10,000 |
NET | > 10,000 | > 10,000 | > 10,000 |
SERT | > 10,000 | > 10,000 | > 10,000 |
Adenosine receptors | > 10,000 | > 10,000 | > 10,000 |
AMPA | > 10,000 | > 10,000 | > 10,000 |
Beta Receptors | > 10,000 | > 10,000 | > 10,000 |
CB1, CB2 | > 10,000 | > 10,000 | > 10,000 |
DOR, KOR, MOR | > 10,000 | > 10,000 | > 10,000 |
H1-H4 | > 10,000 | > 10,000 | > 10,000 |
Muscarinic receptors | > 10,000 | > 10,000 | > 10,000 |
NMDA | > 10,000 | > 10,000 | > 10,000 |
NOP | > 10,000 | > 10,000 | > 10,000 |
PBR | > 10,000 | > 10,000 | > 10,000 |
Sigma 2 | > 10,000 | > 10,000 | > 10,000 |
Sigma1R | 520 | > 10,000 | > 10,000 |