Automated synthesis and quality control of [99mTc]Tc-PSMA for radioguided surgery (in a [68Ga]Ga-PSMA workflow)

EJNMMI Radiopharmacy and Chemistry

Table 2 Comparison between the automated method described in this article and the methods described in literature

	Aalbersberg et al. (current method)	Robu et al. Single method	Robu et al. Kit method	Kratzik et al.
Method	Automated	Manual	Manual	Manual
Buffer	HEPES	Ammonium acetate & disodium tartrate	Sodium hydrogen phosphate & Sodium tartrate	Unknown
Peptide	40 μg PSMA-I&S (=28.7 nmol)	20–30 nmol PSMA-I&S	25 nmol PSMA-I&S	PSMA-I&S (unknown quantity)
Temperature and time	100 °C 20 min	90 °C 20 min	90 °C 20 min	100 °C 10 min
C⁻¹⁸cartridge purification	Yes	Yes	No	No