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EJNMMI Radiopharmacy and Chemistry

Table 3 Amounts of HEPES in different 68Ga-radiopharmaceuticals obtained from different institutes and analyzed by the HPLC method (n = the number of samples from different batches)

From: New sensitive method for HEPES quantification in 68Ga-radiopharmaceuticals

 

[68Ga]Ga-DOTATOC

HEPES

(μg/mL)

Maximum amount in VInj (μg) a

Maximum

VInj (mL)

Institute A (n = 3)

21 ± 4

171 ± 35

10 ± 2

Institute B (n = 6)

19 ± 8

150 ± 60

11 ± 1

Institute C

____

____

____

 

[68Ga]Ga-PSMA-11

Institute A (n = 3)

7 ± 10

58 ± 81

14 ± 3b

Institute B (n = 5)

8 ± 7

64 ± 54

16 ± 3b

Institute C

____

____

____

 

[68Ga]Ga-NODAGA-Exendin

Institute A (n = 3)

31 ± 1§

291 ± 39

6 ± 1

Institute B (n = 3)

36 ± 5§

245 ± 12

6 ± 1

Institute C (n = 3)

60 ± 8*

482 ± 69

2 ± 1

  1. a When considering the recommended volume of injection of 8 mL. b When the amounts of HEPES were below LOQ, the total volume of the radiopharmaceutical (VT = 16 mL) was considered the maximum injected volume. §p < 0.05 when comparing the HEPES concentration present in different radiopharmaceuticals obtained from the same institute.* p < 0.05 when comparing the HEPES concentration present in the same radiopharmaceutical obtained in different institutes
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