Fig. 5

In vivo biodistribution of [¹⁸F]AlF-NOTA-octreotide in control and blocking (co-injection with 2.5 mg/kg octreotide). a) Maximum intensity projections of PET, MRI and PET/MRI fusion data at 60–70 min post-injection, with SSTR2-expressing organs (pituitary and adrenal glands, pancreas) highlighted by arrows in representative naïve (left) and blocked (right) animals. MR images were acquired in two bed positions with at least 20% overlap. Images shown above were generated after fusion of both images. b) Single slice image at 60–70 min post-injection centered on the right adrenal gland (circled in white) to illustrate MR-guided organ delineation. c) Organ concentration of [¹⁸F]AlF-NOTA-octreotide at 2 h post injection for selected organs (n = 3) in control (left) and blocking (right) conditions