Table 1 Overview on evaluation batches and overall yield of [11C]metoclopramide productions with changing reaction conditions
From: Pitfalls and solutions of the fully-automated radiosynthesis of [11C]metoclopramide
Solvent | Reactive synthon | RCY (% based on [11C]CO2, decay corrected) | Activity yield [GBq] |
|---|---|---|---|
Acetone (n = 3) | [11C]CH3OTf | 20.7 ± 4.5% | 5.4 ± 1.2 |
Butanone (n = 3, evaluation batches) | [11C]CH3OTf | 20.8 ± 3.8% | 6.3 ± 1.7 |
Butanone (n = 1) | [11C]CH3I | no product | 0 |
Butanone (n = 94, overall productions) | [11C]CH3OTf | 13.2 ± 6.7 | 3.9 ± 2.0 |