Skip to main content

Table 2 Comparison of performance of the microvolume droplet synthesis of [18F]FET and published results using conventional methods

From: Rapid, efficient, and economical synthesis of PET tracers in a droplet microreactor: application to O-(2-[18F]fluoroethyl)-L-tyrosine ([18F]FET)

 

This work

(Hamacher and Coenen 2002)

(Bourdier et al. 2011)

(Lakshminarayanan et al. 2016)

(Iwata et al. 2018)

(Yanai et al. 2019)

(Bouvet et al. 2012)

Reaction format

Droplet

Conventional

Conventional

Conventional

Small volume in vial

Small volume in vial

Flow-through / capillary

Reactor type

Droplet microreactor

Custom FDG module

TracerLab FXFN

Modified GE TracerLab FX-C

300μL Reacti-vial

300μL Reacti-vial

Advion NanoTek® capillary reactor

Precursor amount (nmol)

60

14800

9000

13280

180-350

350

59d

Starting activity (GBq)

0.4±0.1 (n=4)

N/R

18-41 (n=22)

N.R.

<0.4

0.95-2.6 (n=9)

0.005-0.2d (n=?)

Reaction volume (μL)

10

500

2000

1000

10-20

20-30

20

Overall RCY (non decay-corrected, %)

55±7 (n=4)

33-36 (n=?)

35±5 (n=22)

19±1 (n=?)

N. R. c (n=3~6)

38±6 (n=9)

38 (n=?)

Synthesis time a (min)

40

80

63

N.R.

N.R.

60

<45

Molar activity (GBq/μmol)

56-140

>18

>90

N.R. b

N.R.

570±240 (n=9)

N.R.

  1. N.R. not reported
  2. aSynthesis time includes purification and formulation, except Bouvet et al. which does not include formulation
  3. bThe paper assumes the molar activity value of the tracer is the same as the [18F]fluoride in the irradiated target, which is not valid
  4. cThe decay-corrected RCY was reported as 34–64%, but no synthesis time was given, so an estimate of the non-decay corrected RCY could not be made.
  5. dUnlike the other reaction formats, increasing the scale in a flow-through reactor requires increased reagent volumes and increased precursor consumption