Table 1 Summary of performance of microdroplet synthesis of [18F]FET with optimized manual operation or automated operation. All values are decay-corrected unless otherwise specified
Manual (n = 4) | Automated (n = 5) | |
|---|---|---|
Collection efficiency (%) | 64 ± 5 | 59 ± 10 |
Residual chip activity (%) | 1.3 ± 0.5 | 3 ± 1 |
Volatile activity loss (%) | 35 ± 6 | 38 ± 11 |
Fluorination yield (%) | 62 ± 8 | 59 ± 10 |
Radiochemical conversion to FET (%) | 92 ± 4 | 93 ± 6 |
Deprotection efficiency (%) | 96 ± 2 | 93 ± 6 |
Crude RCY (%) | 59 ± 7 | 54 ± 6 |
Crude synthesis time (min) | 24 ± 2 | 19 ± 2 |
Crude RCY, non-decay-corrected (%) | 51 ± 6 | 48 ± 5 |