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Fig. 8 | EJNMMI Radiopharmacy and Chemistry

Fig. 8

From: Auger electrons for cancer therapy – a review

Fig. 8

a Treatment of athymic mice with subcutaneous HER2-positive MDA-MB-361 human breast cancer xenografts with a single injection of 111In-NLS-trastuzumab (9.25 MBq; 4 mg/kg) significantly slowed tumour growth compared to control mice receiving unlabelled trastuzumab (4 mg/kg) or normal saline. b Treatment of tumour-bearing mice with two injections of 111In-NLS-trastuzumab (9.25 MBq; 4 mg/kg) significantly prolonged survival compared to control mice receiving unlabelled trastuzumab or normal saline (Costantini et al. 2010)

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