Fig. 10

a Treatment of athymic mice with subcutaneous EGFR-positive MDA-MB-468 human breast cancer xenografts with 5 weekly amounts of ¹¹¹In-DTPA-hEGF (cumulative dose, 92.5 MBq; 17 μg). Auger electron (AE) radiotherapy was effective compared to control mice treated with normal saline, but the growth of smaller, non-established tumours (right panel) was more strongly inhibited than larger tumours (left panel) (Chen et al. 2003). b SPECT and corresponding CT images of two patients at 24 h after injection of ¹¹¹In-DTPA-hEGF in a Phase 1 clinical trial, demonstrating uptake into a recurrent primary breast cancer (left panels) or a lung metastasis (right panels) (Vallis et al. 2014)