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Table 3 Stability of 225Ac-labelled chelate complexes in human serum at ambient Temperatures (n = 3 unless otherwise noted)

From: Evaluation of polydentate picolinic acid chelating ligands and an α-melanocyte-stimulating hormone derivative for targeted alpha therapy using ISOL-produced 225Ac

225Ac-complex

Time Point

% Stable

0.5 h

1 h

4 h

1 d

2 d

3 d

4 d

7 d

[225Ac(octapa)]

NDa

97.9 ± 0.9

96.9 ± 1.5

94.9 ± 1.2

96.1 ± 1.0

94.9 ± 1.1

95.9 ± 1.9

92.9 ± 1.0

[225Ac(CHXoctapa)]− b

NDa

95.9 ± 1.0

96.8 ± 1.7

97.0 ± 0.9

96.7 ± 1.6

96.1 ± 1.5

96.7 ± 1.2

95.6 ± 1.6

[225Ac(phospa)]3−

NDa

81.6 ± 1.1

NDa

81.5 ± 0.2

NDa

80.2 ± 1.1

76.2 ± 0.1

77.1 ± 6.4

[225Ac(DOTA)]

92.4 ± 4.0

93.9 ± 4.5

94.4 ± 3.7

90.9 ± 5.6

91.8 ± 5.6

NDa

91.1 ± 6.1

84.7 ± 8.1

[225Ac(macropa)]+ (Thiele et al. 2017) c

96

95

93

90

93

90

NDa

90

[225Ac(bispa2)]+ (Comba et al. 2017)

NDa

97.4 ± 0.5

NDa

92.3 ± 0.7

NDa

90.7 ± 0.5

NDa

88.9 ± 2.8

Control

1.45 ± 3.8

1.29 ± 4.0

1.6 ± 3.5

2.6 ± 5.0

3.9 ± 3.0

NDa

0.96 ± 3.3

1.5 ± 4.1

  1. aND not determined; bn = 4; cn = 1