Fig. 1From: AAZTA5/AAZTA5-TOC: synthesis and radiochemical evaluation with 68Ga, 44Sc and 177LuSynthesis of the bifunctional chelator AAZTA5: (i) A21, MeOH, in situ; (ii) paraformaldehyde, MeOH, yield 85%; (iii) Pd (OH)2/C, EtOH, H2, not isolated; (iv) tert-butyl-bromoacetate, K2CO3, ACN, yield (iii/iv) 55%; (v) LiOH, dioxane/water, yield 80%; (vi) 90% TFA/5% H2O/5% triisopropylsilane (TiS), yield 60% after HPLCBack to article page