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EJNMMI Radiopharmacy and Chemistry
Fig. 5 | EJNMMI Radiopharmacy and Chemistry

Fig. 5

From: Automated preparation of clinical grade [68Ga]Ga-DOTA-CP04, a cholecystokinin-2 receptor agonist, using iPHASE MultiSyn synthesis platform

Fig. 5

Addition of varying amounts of chloramine-T oxidant to [68Ga]Ga-DOTA-CP04 increases % formation of [68Ga]Ga-DOTA-CP04-oxidised material. Black chromatogram represents initial constituents of [68Ga]Ga-DOTA-CP04 for injection (93.8% pure) without the addition of any oxidants. [68Ga]Ga-DOTA-CP04 purity is reduced to 76.8% and the oxidized material increases to 21.14% in the presence of 0.439 μM chloramine-T oxidant (pink chromatogram). In the presence of 4.39 μM chloramine-T oxidant, [68Ga]Ga-DOTA-CP04 is completely consumed to form the oxidized material (93.4%) and one other impurity eluting directly after [68Ga]Ga-DOTA-CP04

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