EJNMMI Radiopharmacy and Chemistry

Table 2 Optimisation of reaction conditions for radiolabelling [¹¹C] PIB from direct [¹¹C]CO₂ incorporation

From: Fully-automated radiosynthesis of the amyloid tracer [¹¹C] PiB via direct [¹¹C]CO₂ fixation-reduction

[a] Experiments were performed using approximately 18.5 GBq of [¹¹C]CO₂ as a starting activity from the cyclotron; [b] ‘cold’ and ‘hot’ flushes of targets and lines; [c] solution sparged with He (5 min, 40 mL/min); [d] without [¹¹C]CO₂, [e] without [¹¹C]CO₂ and without PhSiH₃ / TBAF, [f] n = 3

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