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Table 1 Full timecourse biodistribution study of gallium-68 labeled Ex4NOD and Ex4DFO, given as percent injected activity per gram tissue (% i.A/g)

From: Comparison of desferrioxamine and NODAGA for the gallium-68 labeling of exendin-4

 

Ex4NOD

Ex4DFO

Ex4NOD

Ex4DFO

Ex4NOD

Ex4DFO

0.5 h p.i.

1 h p.i.

1 h p.i., blocked

Blood

1.98 ± 0.17

1.51 ± 0.12

0.86 ± 0.22

0.94 ± 0.11

0.86 ± 0.13

1.30 ± 0.19

Heart

2.00 ± 0.20

1.47 ± 0.10

1.53 ± 0.12

1.19 ± 0.14

1.73 ± 0.41

1.55 ± 0.25

Lung

67.61 ± 10.82

44.98 ± 4.01

78.30 ± 9.65

36.94 ± 1.34**

1.80 ± 0.32

1.94 ± 0.25

Spleen

1.79 ± 0.33

1.18 ± 0.21

1.58 ± 0.40

1.51 ± 0.08

2.11 ± 0.44

2.21 ± 0.38

Kidneys

393.24 ± 77.01

165.93 ± 29.22****

524.73 ± 97.35

105.27 ± 29.56****

204.74 ± 28.85

180.89 ± 37.02

Pancreas

22.21 ± 1.87

14.08 ± 1.75

26.17 ± 5.48

10.05 ± 1.25

1.46 ± 0.03

1.67 ± 0.08

Stomach

5.93 ± 2.48

3.27 ± 1.02

6.63 ± 1.78

2.05 ± 0.26

1.39 ± 0.18

1.66 ± 0.13

Intestines

3.71 ± 0.27

3.43 ± 0.49

4.09 ± 0.90

3.47 ± 0.88

1.56 ± 0.68

2.97 ± 0.54

Liver

1.50 ± 0.15

1.38 ± 0.14

1.56 ± 0.36

1.10 ± 0.25

0.98 ± 0.12

1.84 ± 0.10

Muscle

1.13 ± 0.07

0.82 ± 0.08

1.24 ± 0.35

0.96 ± 0.10

2.15 ± 0.52

1.88 ± 0.37

Bone

2.00 ± 0.17

1.39 ± 0.35

2.08 ± 0.87

1.79 ± 0.58

12.42 ± 11.02

9.51 ± 3.75

Tumor

36.29 ± 8.93

23.54 ± 5.70

46.18 ± 13.72

15.1 ± 2.67

5.89 ± 1.43

4.13 ± 1.22

  1. The values are averages of four mice, given ± SD (α = 0.05), where ** is p < 0.01, and **** is p < 0.0001