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Table 1 Full timecourse biodistribution study of gallium-68 labeled Ex4NOD and Ex4DFO, given as percent injected activity per gram tissue (% i.A/g)

From: Comparison of desferrioxamine and NODAGA for the gallium-68 labeling of exendin-4

  Ex4NOD Ex4DFO Ex4NOD Ex4DFO Ex4NOD Ex4DFO
0.5 h p.i. 1 h p.i. 1 h p.i., blocked
Blood 1.98 ± 0.17 1.51 ± 0.12 0.86 ± 0.22 0.94 ± 0.11 0.86 ± 0.13 1.30 ± 0.19
Heart 2.00 ± 0.20 1.47 ± 0.10 1.53 ± 0.12 1.19 ± 0.14 1.73 ± 0.41 1.55 ± 0.25
Lung 67.61 ± 10.82 44.98 ± 4.01 78.30 ± 9.65 36.94 ± 1.34** 1.80 ± 0.32 1.94 ± 0.25
Spleen 1.79 ± 0.33 1.18 ± 0.21 1.58 ± 0.40 1.51 ± 0.08 2.11 ± 0.44 2.21 ± 0.38
Kidneys 393.24 ± 77.01 165.93 ± 29.22**** 524.73 ± 97.35 105.27 ± 29.56**** 204.74 ± 28.85 180.89 ± 37.02
Pancreas 22.21 ± 1.87 14.08 ± 1.75 26.17 ± 5.48 10.05 ± 1.25 1.46 ± 0.03 1.67 ± 0.08
Stomach 5.93 ± 2.48 3.27 ± 1.02 6.63 ± 1.78 2.05 ± 0.26 1.39 ± 0.18 1.66 ± 0.13
Intestines 3.71 ± 0.27 3.43 ± 0.49 4.09 ± 0.90 3.47 ± 0.88 1.56 ± 0.68 2.97 ± 0.54
Liver 1.50 ± 0.15 1.38 ± 0.14 1.56 ± 0.36 1.10 ± 0.25 0.98 ± 0.12 1.84 ± 0.10
Muscle 1.13 ± 0.07 0.82 ± 0.08 1.24 ± 0.35 0.96 ± 0.10 2.15 ± 0.52 1.88 ± 0.37
Bone 2.00 ± 0.17 1.39 ± 0.35 2.08 ± 0.87 1.79 ± 0.58 12.42 ± 11.02 9.51 ± 3.75
Tumor 36.29 ± 8.93 23.54 ± 5.70 46.18 ± 13.72 15.1 ± 2.67 5.89 ± 1.43 4.13 ± 1.22
  1. The values are averages of four mice, given ± SD (α = 0.05), where ** is p < 0.01, and **** is p < 0.0001