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Fig. 3 | EJNMMI Radiopharmacy and Chemistry

Fig. 3

From: Synthesis of a benzoxazinthione derivative of tanaproget and pharmacological evaluation for PET imaging of PR expression

Fig. 3

In vitro characterisation of [18F]2 in breast cancer cell lines with varying PR expression levels. a Western Blot showing PR expression in cell lines and in ovarian of C57BL/6 female mice with or without gonadotropic stimulation of PR expression (+/− HT). b Uptake of [18F]2 in three cell lines. c Blocking [18F]2 uptake in T47D cells treated with progesterone (0.01–1 μM). Error bars indicate standard errors from n = 3 repeats. Significances are marked with asterisk, (*) and (**) P ≤ 0.05, P ≤ 0.01, respectively

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