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EJNMMI Radiopharmacy and Chemistry

Table 1 Optimization of reaction conditions for radiosynthesis of [18F]3

From: Synthesis and preliminary preclinical evaluation of fluorine-18 labelled isatin-4-(4-methoxyphenyl)-3-thiosemicarbazone ([18F]4FIMPTC) as a novel PET tracer of P-glycoprotein expression

Solvent 0.5 mL Precursor
(μmol) 		Temperature
(°C) 		Kryptofix
(μmol) 		K2CO3
(μmol) 		Yield
(%)
DMSO 26 120 6 3 6%
DMSO 24 140 6 3 7%
DMSO 54 140 6 3 5%
DMSO 26 160 6 3 4%
MeCN 26 140 6 3 1%
MeCN 24 140 18 9 2%
DMSO 16 140 6 3 3%
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