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EJNMMI Radiopharmacy and Chemistry

Table 1 Optimization of reaction conditions for radiosynthesis of [18F]3

From: Synthesis and preliminary preclinical evaluation of fluorine-18 labelled isatin-4-(4-methoxyphenyl)-3-thiosemicarbazone ([18F]4FIMPTC) as a novel PET tracer of P-glycoprotein expression

Solvent 0.5 mL

Precursor

(μmol)

Temperature

(°C)

Kryptofix

(μmol)

K2CO3

(μmol)

Yield

(%)

DMSO

26

120

6

3

6%

DMSO

24

140

6

3

7%

DMSO

54

140

6

3

5%

DMSO

26

160

6

3

4%

MeCN

26

140

6

3

1%

MeCN

24

140

18

9

2%

DMSO

16

140

6

3

3%

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