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Table 1 Comparison of the productions starting from either [11C]CO2 or [11C]CH4

From: Comparison of fully-automated radiosyntheses of [11C]erlotinib for preclinical and clinical use starting from in target produced [11C]CO2 or [11C]CH4

Parameter

Method 1 ([11C]CO2)

Method 2 ([11C]CH4)

Number of syntheses

94

35

Yield in GBq (EOS)

2.6 ± 1.3 GBq

0.76 ± 0.27 GBq

Yield in % (decay-corrected to [11C]CH3I)

13.4 ± 6.2%

16.1 ± 4.9%

Molar activity (EOS)

88 ± 57 GBq/μmol

157 ± 68 GBq/μmol

Irradiation time

30–40 min

25 min

Overall synthesis time (EOB)

approx. 35 min

approx. 34 min

  1. EOS end of synthesis, EOB end of bombardment