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Table 3 99mTc production pathways

From: Production of novel diagnostic radionuclides in small medical cyclotrons

Reaction Method Currently available Status and further development
235U(n,f)99Mo → 99mTc Reactor + generator Worldwide Well-established, availability will shrink with phasing out of nuclear research reactors
100Mo(p,2n)99mTc Small medical or intermediate energy cyclotron In Canada Possible worldwide implementation with decreasing nuclear reactor capacity
96Zr(α,n)99Mo → 99mTc α beam cyclotron + generator No Will not be implemented. Method not competitive, α-beam required, low yields
100Mo(γ,n)99Mo → 99mTc LINAC+ generator No Under development in Canada, USA and the Netherlands
98Mo(n,γ)99Mo → 99mTc Reactor + generator In USA and Japan Auxiliary method used in nuclear reactors (Blaauw et al., 2017; van der Marck, Koning, and Charlton, 2010). Availability will shrink with phasing out of nuclear research reactors
100Mo(p,2n)99mTc Laser No Theoretically feasible. Further research required