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Table 1 Biodistribution data of [18F]2 in nude mice bearing CHL-GLP-1 receptor positive tumor xenografts

From: Radiosynthesis and evaluation of an 18F–labeled silicon containing exendin-4 peptide as a PET probe for imaging insulinoma

Organ or tissue 30 min p.i. (n = 4) 60 min p.i. (n = 4) 60 min p.i. (n = 4) blockade 120 min p.i. (n = 4)
%ID/g in
 Blood 9.7 ± 1.1 6.9 ± 2.2 11.1 ± 0.6 3.3 ± 0.8
 Lungsa 15.1 ± 1.5 15 ± 4 10.0 ± 0.4 11.4 ± 2.1
 Spleen 2.9 ± 0.3 2.4 ± 0.8 3.5 ± 0.1 1.6 ± 0.5
 Kidneys 33.3 ± 2.4 49 ± 18 79 ± 5 39 ± 12
 Pancreasa 4.2 ± 0.6 4.4 ± 1.4 6 ± 4 3.2 ± 0.6
 Stomacha 1.8 ± 0.7 1.3 ± 0.2 1.0 ± 0.1 1.0 ± 0.7
 Intestines 3.0 ± 0.3 5.4 ± 0.8 5.3 ± 1.2 7 ± 4
 Liver 6.4 ± 0.7 7.7 ± 2.1 10.60 ± 0.30 5.0 ± 1.1
 Muscle 1.5 ± 0.4 1.1 ± 0.4 1.73 ± 0.13 0.61 ± 0.12
 Bone 1.8 ± 0.3 2.0 ± 0.7 2.87 ± 0.20 1.9 ± 0.5
 Tumora 15 ± 7 14 ± 7* 7 ± 1* 13 ± 10
  1. Mice were injected with [18F]2 (200 kBq, 1.3 pmol) via the lateral tail vein. In the blockade group, each animal received nonradioactive precursor 1 (100 μg, 22 nmol) in PBS co-injected with tracer [18F]2 (266 kBq, 1.7 pmol)
  2. *Values are significantly different (unpaired, two populations, Student t-test, P < 0.03)
  3. aGLP-1 receptor-positive organs