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Table 1 Biodistribution data of [18F]2 in nude mice bearing CHL-GLP-1 receptor positive tumor xenografts

From: Radiosynthesis and evaluation of an 18F–labeled silicon containing exendin-4 peptide as a PET probe for imaging insulinoma

Organ or tissue

30 min p.i. (n = 4)

60 min p.i. (n = 4)

60 min p.i. (n = 4) blockade

120 min p.i. (n = 4)

%ID/g in

 Blood

9.7 ± 1.1

6.9 ± 2.2

11.1 ± 0.6

3.3 ± 0.8

 Lungsa

15.1 ± 1.5

15 ± 4

10.0 ± 0.4

11.4 ± 2.1

 Spleen

2.9 ± 0.3

2.4 ± 0.8

3.5 ± 0.1

1.6 ± 0.5

 Kidneys

33.3 ± 2.4

49 ± 18

79 ± 5

39 ± 12

 Pancreasa

4.2 ± 0.6

4.4 ± 1.4

6 ± 4

3.2 ± 0.6

 Stomacha

1.8 ± 0.7

1.3 ± 0.2

1.0 ± 0.1

1.0 ± 0.7

 Intestines

3.0 ± 0.3

5.4 ± 0.8

5.3 ± 1.2

7 ± 4

 Liver

6.4 ± 0.7

7.7 ± 2.1

10.60 ± 0.30

5.0 ± 1.1

 Muscle

1.5 ± 0.4

1.1 ± 0.4

1.73 ± 0.13

0.61 ± 0.12

 Bone

1.8 ± 0.3

2.0 ± 0.7

2.87 ± 0.20

1.9 ± 0.5

 Tumora

15 ± 7

14 ± 7*

7 ± 1*

13 ± 10

  1. Mice were injected with [18F]2 (200 kBq, 1.3 pmol) via the lateral tail vein. In the blockade group, each animal received nonradioactive precursor 1 (100 μg, 22 nmol) in PBS co-injected with tracer [18F]2 (266 kBq, 1.7 pmol)
  2. *Values are significantly different (unpaired, two populations, Student t-test, P < 0.03)
  3. aGLP-1 receptor-positive organs