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EJNMMI Radiopharmacy and Chemistry

Table 3 Ex vivo biodistribution of [177Lu]DOTAZOL in healthy Wistar rats after 1 h, 1 and 8 days p.i. , expressed in terms of %ID per organ and per gram tissue, respectively

From: Bone targeting compounds for radiotherapy and imaging: *Me(III)-DOTA conjugates of bisphosphonic acid, pamidronic acid and zoledronic acid

Organ % ID per Organ % ID per gram
1 h 24 h 8 d 1 h 24 h 8 d
Lung 0.06 (0.01) 0.01 (0.00) 0.00 (0.00) 0.08 (0.02) 0.01 (0.01) 0.00 (0.00)
Liver 0.40 (0.13) 0.21 (0.07) 0.24 (0.04) 0.09 (0.04) 0.02 (0.01) 0.03 (0.01)
Spleen 0.01 (0.00) 0.01 (0.00) 0.01 (0.00) 0.05 (0.01) 0.02 (0.02) 0.02 (0.01)
Kidneys 1.78 (0.13) 1.64 (0.20) 0.10 (0.02) 1.70 (0.13) 1.25 (0.11) 0.07 (0.01)
Muscle 0.04 (0.02) 0.00 (0.00) 0.00 (0.00) 0.02 (0.00) 0.00 (0.00) 0.00 (0.00)
Heart 0.02 (0.00) 0.00 (0.00) 0.00 (0.00) 0.04 (0.01) 0.00 (0.00) 0.00 (0.00)
Blood 0.56 (0.07) 0.00 (0.00) 0.00 (0.00) 0.07 (0.01) 0.00 (0.00) 0.00 (0.00)
Intestine 1.59 (0.13) 0.38 (0.25) 0.29 (0.21) 0.08 (0.03) 0.02 (0.02) 0.02 (0.02)
Femur 2.11 (0.22) 1.89 (0.11) 2.25 (0.11) 3.43(0.41) 3.20 (0.40) 3.03 (0.17)
Skeleton 44.62 (5.00) 44.79 (4.82) 44.78 (3.71) - - -
  1. Each value represents the mean (S.D.) for four animals
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