Skip to main content

Table 1 Ex vivo biodistribution of [68Ga]DOTAPAM, [68Ga]DOTAZOL, [68Ga]BPAPD and [18F]NaF in healthy Wistar rats after 60 min p. i

From: Bone targeting compounds for radiotherapy and imaging: *Me(III)-DOTA conjugates of bisphosphonic acid, pamidronic acid and zoledronic acid

Organ

[68Ga]DOTAPAM

[68Ga]DOTAZOL

[68Ga]BPAPDa

[18F]NaFa

Lung

0.53 (0.16) b

0.45 (0.11) b

0.43 (0.08)

0.05 (0.01)

Liver

0.43 (0.04) b,d

0.28 (0.03) b,d

0.37 (0.11)

0.03 (0.01)

Spleen

0.31 (0.04) b,d

0.17 (0.02) b,d

0.23 (0.08)

0.13 (0.20)

Kidneys

0.48 (0.06) b

0.53 (0.04) b

0.56 (0.08)

0.11 (0.01)

Muscle

0.09 (0.02) c

0.08 (0.02) c

0.17 (0.02)

0.06 (0.05)

Heart

0.23 (0.02) b,c,d

0.14 (0.04) b,c,d

0.32 (0.09)

0.02 (0.01)

Blood

0.60 (0.03) b,c

0.47 (0.19) b,c

0.86 (0.21)

0.05 (0.01)

Intestine

0.28 (0.12) b

0.14 (0.08) b

0.26 (0.05)

0.02 (0.01)

Femur

4.53 (0.17) c,d

5.40 (0.62) c,d

3.21 (0.29)

4.87 (0.32)

  1. Data are expressed in SUV. Each value represents the mean (S.D.) for five animals
  2. a Data taken from (Meckel et al. 2013)
  3. b P < 0.05 vs. [18F]NaF
  4. c P < 0.05 vs. [68Ga]BPAPD
  5. d P < 0.05 [68Ga]DOTAPAM vs. [68Ga]DOTAZOL