Bone targeting compounds for radiotherapy and imaging: *Me(III)-DOTA conjugates of bisphosphonic acid, pamidronic acid and zoledronic acid

EJNMMI Radiopharmacy and Chemistry

Table 1 Ex vivo biodistribution of [⁶⁸Ga]DOTA^PAM, [⁶⁸Ga]DOTA^ZOL, [⁶⁸Ga]BPAPD and [¹⁸F]NaF in healthy Wistar rats after 60 min p. i

Organ	[⁶⁸Ga]DOTA^PAM	[⁶⁸Ga]DOTA^ZOL	[⁶⁸Ga]BPAPD^a	[¹⁸F]NaF^a
Lung	0.53 (0.16) ^b	0.45 (0.11) ^b	0.43 (0.08)	0.05 (0.01)
Liver	0.43 (0.04) ^b,d	0.28 (0.03) ^b,d	0.37 (0.11)	0.03 (0.01)
Spleen	0.31 (0.04) ^b,d	0.17 (0.02) ^b,d	0.23 (0.08)	0.13 (0.20)
Kidneys	0.48 (0.06) ^b	0.53 (0.04) ^b	0.56 (0.08)	0.11 (0.01)
Muscle	0.09 (0.02) ^c	0.08 (0.02) ^c	0.17 (0.02)	0.06 (0.05)
Heart	0.23 (0.02) ^b,c,d	0.14 (0.04) ^b,c,d	0.32 (0.09)	0.02 (0.01)
Blood	0.60 (0.03) ^b,c	0.47 (0.19) ^b,c	0.86 (0.21)	0.05 (0.01)
Intestine	0.28 (0.12) ^b	0.14 (0.08) ^b	0.26 (0.05)	0.02 (0.01)
Femur	4.53 (0.17) ^c,d	5.40 (0.62) ^c,d	3.21 (0.29)	4.87 (0.32)

Data are expressed in SUV. Each value represents the mean (S.D.) for five animals
^a Data taken from (Meckel et al. 2013)
^b P < 0.05 vs. [¹⁸F]NaF
^c P < 0.05 vs. [⁶⁸Ga]BPAPD
^d P < 0.05 [⁶⁸Ga]DOTA^PAM vs. [⁶⁸Ga]DOTA^ZOL