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Table 1 Ex vivo biodistribution of [68Ga]DOTAPAM, [68Ga]DOTAZOL, [68Ga]BPAPD and [18F]NaF in healthy Wistar rats after 60 min p. i

From: Bone targeting compounds for radiotherapy and imaging: *Me(III)-DOTA conjugates of bisphosphonic acid, pamidronic acid and zoledronic acid

Organ [68Ga]DOTAPAM [68Ga]DOTAZOL [68Ga]BPAPDa [18F]NaFa
Lung 0.53 (0.16) b 0.45 (0.11) b 0.43 (0.08) 0.05 (0.01)
Liver 0.43 (0.04) b,d 0.28 (0.03) b,d 0.37 (0.11) 0.03 (0.01)
Spleen 0.31 (0.04) b,d 0.17 (0.02) b,d 0.23 (0.08) 0.13 (0.20)
Kidneys 0.48 (0.06) b 0.53 (0.04) b 0.56 (0.08) 0.11 (0.01)
Muscle 0.09 (0.02) c 0.08 (0.02) c 0.17 (0.02) 0.06 (0.05)
Heart 0.23 (0.02) b,c,d 0.14 (0.04) b,c,d 0.32 (0.09) 0.02 (0.01)
Blood 0.60 (0.03) b,c 0.47 (0.19) b,c 0.86 (0.21) 0.05 (0.01)
Intestine 0.28 (0.12) b 0.14 (0.08) b 0.26 (0.05) 0.02 (0.01)
Femur 4.53 (0.17) c,d 5.40 (0.62) c,d 3.21 (0.29) 4.87 (0.32)
  1. Data are expressed in SUV. Each value represents the mean (S.D.) for five animals
  2. a Data taken from (Meckel et al. 2013)
  3. b P < 0.05 vs. [18F]NaF
  4. c P < 0.05 vs. [68Ga]BPAPD
  5. d P < 0.05 [68Ga]DOTAPAM vs. [68Ga]DOTAZOL