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Table 1 Overview Aß tracers

From: New protein deposition tracers in the pipeline

Tracer name

Chemical structure

Features

Benzothiazole derivatives

 [11C]-PiB (Klunk et al. 2004)

• Investigational

 [18F]-flutemetamol (VizamylTM) (GE Healthcare 2014)

• Approved for clinical use

• Injected dose: 185 MBq

• Effective dose: 5.9 mSv (32 μSv/MBq)

• Imaging window: 90-110 min p.i.

• Scan duration: 20 min

• Visual assessment: color

Benzofuran derivative

 [18F]-NAV4694 (formerly AZD4694) (Cselényi et al. 2012)

• Investigational

Stilbene derivatives

 [18F]-florbetaben (NeuraCeqTM) (Piramal Imaging 2014)

• Approved for clinical use

• Injected dose: 300 MBq

• Effective dose: 5.8 mSv (19 μSv/MBq)

• Imaging window: 90-110 min p.i.

• Scan duration: 20 min

• Visual assessment: grey scale

 [18F]-florbetapir (AmyvidTM) (Eli Lilly 2013)

• Approved for clinical use

• Injected dose: 370 MBq

• Effective dose: 7.0 mSv (19 μSv/MBq)

• Imaging window: 30-50 min p.i.

• Scan duration: 10 min

• Visual assessment: grey scale