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Table 1 Overview Aß tracers

From: New protein deposition tracers in the pipeline

Tracer name Chemical structure Features
Benzothiazole derivatives
 [11C]-PiB (Klunk et al. 2004) • Investigational
 [18F]-flutemetamol (VizamylTM) (GE Healthcare 2014) • Approved for clinical use
• Injected dose: 185 MBq
• Effective dose: 5.9 mSv (32 μSv/MBq)
• Imaging window: 90-110 min p.i.
• Scan duration: 20 min
• Visual assessment: color
Benzofuran derivative
 [18F]-NAV4694 (formerly AZD4694) (Cselényi et al. 2012) • Investigational
Stilbene derivatives
 [18F]-florbetaben (NeuraCeqTM) (Piramal Imaging 2014) • Approved for clinical use
• Injected dose: 300 MBq
• Effective dose: 5.8 mSv (19 μSv/MBq)
• Imaging window: 90-110 min p.i.
• Scan duration: 20 min
• Visual assessment: grey scale
 [18F]-florbetapir (AmyvidTM) (Eli Lilly 2013) • Approved for clinical use
• Injected dose: 370 MBq
• Effective dose: 7.0 mSv (19 μSv/MBq)
• Imaging window: 30-50 min p.i.
• Scan duration: 10 min
• Visual assessment: grey scale