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Table 2 Tumor-to-background ratios at different time points after injection of 44Sc/68Ga-labeled DOTA-RGD and NODAGA-RGD

From: 44Sc for labeling of DOTA- and NODAGA-functionalized peptides: preclinical in vitro and in vivo investigations

 

44Sc-DOTA-RGD

68Ga-DOTA-RGD

U87MG

30 min p.i.

2 h p.i.

5 h p.i.

30 min p.i.

2 h p.i.

Tumor-to-blood

4.82 ± 1.60

40.1 ± 15.6

47.2 ± 18.0

4.34 ± 0.57

28.0 ± 4.26

Tumor-to-liver

0.99 ± 0.14

0.61 ± 0.04

2.90 ± 0.38

0.55 ± 0.09

0.48 ± 0.07

Tumor-to-kidney

1.16 ± 0.29

1.77 ± 0.13

1.82 ± 0.21

0.88 ± 0.07

1.74 ± 0.19

 

44Sc-NODAGA-RGD

68Ga-NODAGA-RGD

U87MG

30 min p.i.

2 h p.i.

5 h p.i.

30 min p.i.

2 h p.i.

Tumor-to-blood

4.73 ± 1.24

34.1 ± 7.62

30.5 ± 9.93

4.17 ± 0.47

114 ± 35.0

Tumor-to-liver

3.02 ± 0.40

3.01 ± 0.13

2.82 ± 0.21

1.72 ± 0.16

1.50 ± 0.20

Tumor-to-kidney

1.18 ± 0.28

2.68 ± 0.14

2.58 ± 0.24

0.89 ± 0.03

1.49 ± 0.21