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Table 2 Concentrations and identification of FDOPA and L-DOPA (g/l) and side products in FDOPA-L and FDOPA-H batches analyzed with UPLC-MS (both n = 6)

From: Improved GMP-compliant multi-dose production and quality control of 6-[18F]fluoro-L-DOPA

FDOPA-L

MC17- cyclotron

FDOPA

214.052 Da

(g/L)

L-DOPA

196.061 Da

(g/L)

6-hydroxy-DL-DOPA

212.056 Da

FDOPA-quinone

212.036 Da

 X ± SD

1.21 ± 0.15

0.04 ± 0.04

-

+

FDOPA-H

Cyclone 18 twin cyclotron

FDOPA

214.052 Da

(g/L)

L-DOPA

196.061 Da

(g/L)

6-hydroxy-DL-DOPA

212.056 Da

FDOPA- quinone

212.036 Da

 X ± SD

0.53 ± 0.10

0.007 ± 0.003

-

-

  1. + = side product detected and – means not detectable