Skip to main content

Advertisement

Table 1 Overview of the different treatment groups (* saline treatment, equivalent volumes)

From: Striatal phosphodiesterase 10A availability is altered secondary to chronic changes in dopamine neurotransmission

Experiment Treatment Injection route Dose (mg/kg) Duration of treatment Time before scan n
1 Amphetamine SC 5 Acute 60 min 6
2 Amphetamine IV 1 Acute 5 min 5
3 Saline (test/retest) SC * Acute 60 min 3
4 Saline (test/retest) IV * Acute 5 min 3
5 Amphetamine SC 5 5 days 4 h 5
6 Amphetamine + SCH23390 SC 5 1 5 days 4 h 6
7 SCH23390 SC 1 5 days 4 h 5
8 Saline SC * 5 days 4 h 3
  1. Rats undergoing acute treatment were scanned at baseline conditions and after acute treatment. The 5 day treatment consisted of a baseline scan, a scan immediately after the 5 day treatment and a scan 10 days after the last treatment