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EJNMMI Radiopharmacy and Chemistry
Fig. 1 | EJNMMI Radiopharmacy and Chemistry

Fig. 1

From: Striatal phosphodiesterase 10A availability is altered secondary to chronic changes in dopamine neurotransmission

Fig. 1

[18F]JNJ42259152 BPND values after acute amphetamine treatment. Left: Transversal images of PDE10A binding in the brain at baseline conditions vs 60 min after s.c. amphetamine treatment (a) and at baseline conditions vs 5 min after i.v. amphetamine treatment (b). Images are overlaid on a VOI map and presented as averaged, parametric BPND images (Logan Reference) at baseline conditions and amphetamine treated conditions. Right: Comparison of BPND in striatum at baseline conditions and 1 h after subcutaneous injection of amphetamine (c) and 5 min after intravenous injection of amphetamine (d). No significant difference was found

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