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EJNMMI Radiopharmacy and Chemistry
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  1. Positron emission tomography (PET) is a powerful tool in medical imaging, especially in combination with the PET radionuclide fluorine-18 that possesses optimal characteristics. For labelling of biomolecules a...

    Authors: Carsten Sven Kramer, Luca Greiner, Klaus Kopka and Martin Schäfer
    Citation: EJNMMI Radiopharmacy and Chemistry 2022 7:15
    Content type: Research article Published on:

  2. This review presents the results of a survey conducted by the International Atomic Energy Agency on cyclotrons and related infrastructure used for radionuclide and radiopharmaceutical production which are supp...

    Authors: Miguel A. Avila-Rodriguez, Amir R. Jalilian, Aruna Korde, David Schlyer, Mohammad Haji-Saeid, Jose Paez and Saul Perez-Pijuan
    Citation: EJNMMI Radiopharmacy and Chemistry 2022 7:14
    Content type: Review Published on:

  3. Tissue hypoxia is a pathological condition characterized by reducing oxygen supply. Hypoxia is a hallmark of tumor environment and is commonly observed in many solid tumors. Non-invasive imaging techniques lik...

    Authors: Arian Pérez Nario, Jenilee Woodfield, Sofia Nascimento dos Santos, Cody Bergman, Melinda Wuest, Yasniel Babí Araújo, André Luis Lapolli, Frederick G. West, Frank Wuest and Emerson Soares Bernardes
    Citation: EJNMMI Radiopharmacy and Chemistry 2022 7:13
    Content type: Research article Published on:

  4. Combining optical (fluorescence) imaging with nuclear imaging has the potential to offer a powerful tool in personal health care, where nuclear imaging offers in vivo functional whole-body visualization, and t...

    Authors: Anthony W. McDonagh, Brooke L. McNeil, Julie Rousseau, Ryan J. Roberts, Helen Merkens, Hua Yang, François Bénard and Caterina F. Ramogida
    Citation: EJNMMI Radiopharmacy and Chemistry 2022 7:12
    Content type: Research article Published on:

  5. The increasing incidence of cancer over the years is one of the most challenging problems in healthcare. As cancer progresses, the recruitment of several immune cells is triggered. Infiltration of tumor-associ...

    Authors: Bruna Fernandes, Paula Kopschina Feltes, Carolina Luft, Luiza Reali Nazario, Cristina Maria Moriguchi Jeckel, Ines F. Antunes, Philip H. Elsinga and Erik F. J. de Vries
    Citation: EJNMMI Radiopharmacy and Chemistry 2022 7:11
    Content type: Review Published on:

  6. Noninvasive molecular imaging using peptides and biomolecules labelled with positron emitters has become important for detection of cancer and other diseases with PET (positron emission tomography). The positr...

    Authors: Raphaël Hoareau, Tore Bach-Gansmo, Paul Cumming and Dag Erlend Olberg
    Citation: EJNMMI Radiopharmacy and Chemistry 2022 7:10
    Content type: Research article Published on:

  7. The Editorial Board of EJNMMI Radiopharmacy and Chemistry releases a biyearly highlight commentary to update the readership on trends in the field of radiopharmaceutical development.

    Authors: Emerson Bernardes, Peter Caravan, R. Michael van Dam, Winnie Deuther-Conrad, Beverley Ellis, Shozo Furumoto, Benjamin Guillet, Ya-Yao Huang, Hongmei Jia, Peter Laverman, Zijing Li, Zhaofei Liu, Filippo Lodi, Yubin Miao, Lars Perk, Ralf Schirrmacher…
    Citation: EJNMMI Radiopharmacy and Chemistry 2022 7:9
    Content type: Review Published on:

  8. Recent advances in nanotechnology have offered new hope for cancer detection, prevention, and treatment. Nanomedicine, a term for the application of nanotechnology in medical and health fields, uses nanopartic...

    Authors: Martha Sahylí Ortega Pijeira, Herlys Viltres, Jan Kozempel, Michal Sakmár, Martin Vlk, Derya İlem-Özdemir, Meliha Ekinci, Seshasai Srinivasan, Amin Reza Rajabzadeh, Eduardo Ricci-Junior, Luciana Magalhães Rebelo Alencar, Mohammed Al Qahtani and Ralph Santos-Oliveira
    Citation: EJNMMI Radiopharmacy and Chemistry 2022 7:8
    Content type: Review Published on:

  9. Prosthetic approach for the radiolabeling of biologics with fluorine-18 is a robust strategy and has been employed for many years. It requires fast, biocompatible and selective reactions suited to these fragil...

    Authors: Mylène Richard, Françoise Hinnen and Bertrand Kuhnast
    Citation: EJNMMI Radiopharmacy and Chemistry 2022 7:7
    Content type: Research article Published on:

  10. The GMP-compliant production of radiopharmaceuticals has been performed using disposable units (cassettes) with a dedicated synthesis module. To expand this “plug ‘n’ synthesize” principle to a broader scope o...

    Authors: Jan Wenz, Felix Arndt and Samuel Samnick
    Citation: EJNMMI Radiopharmacy and Chemistry 2022 7:6
    Content type: Methodology Published on:

  11. Flumazenil (FMZ) is a functionally silent imidazobenzodiazepine which binds to the benzodiazepine binding site of approximately 75% of the brain γ-aminobutyric acid-A receptors (GABAARs). Positron Emission Tomogr...

    Authors: Thibault Gendron, Gianluca Destro, Natan J. W. Straathof, Jeroen B. I. Sap, Florian Guibbal, Charles Vriamont, Claire Caygill, John R. Atack, Andrew J. Watkins, Christopher Marshall, Rebekka Hueting, Corentin Warnier, Véronique Gouverneur and Matthew Tredwell
    Citation: EJNMMI Radiopharmacy and Chemistry 2022 7:5
    Content type: Research article Published on:

  12. Receptor-interacting protein 1 kinase (RIPK1) is a key enzyme in the regulation of cellular necroptosis. Recently, cyclohexyl (5-(2-acetamidobenzo[d]thiazol-6-yl)-2-methylpyridin-3-yl)carbamate (PK68, 5) has been...

    Authors: Tomoteru Yamasaki, Katsushi Kumata, Atsuto Hiraishi, Yiding Zhang, Hidekatsu Wakizaka, Yusuke Kurihara, Nobuki Nengaki and Ming-Rong Zhang
    Citation: EJNMMI Radiopharmacy and Chemistry 2022 7:4
    Content type: Research article Published on:

  13. Pretargeted immuno-PET tumor imaging has emerged as a valuable diagnostic strategy that combines the high specificity of antibody-antigen interaction with the high signal and image resolution offered by short-...

    Authors: Hugo Helbert, Emily M. Ploeg, Douwe F. Samplonius, Simon N. Blok, Ines F. Antunes, Verena I. Böhmer, Gert Luurtsema, Rudi A. J. O. Dierckx, Ben L. Feringa, Philip H. Elsinga, Wiktor Szymanski and Wijnand Helfrich
    Citation: EJNMMI Radiopharmacy and Chemistry 2022 7:3
    Content type: Research article Published on:

  14. The need for a stability evaluation of [18F]FDG is evident. The main purpose of this study was to make recommendations for determining the shelf life based on the available stability literature and our own two-ce...

    Authors: Jes G. Holler, Børge Renmælmo and Richard Fjellaksel
    Citation: EJNMMI Radiopharmacy and Chemistry 2022 7:2
    Content type: Research article Published on:

  16. As 225Ac-labeled radiopharmaceuticals continue to show promise as targeted alpha therapeutics, there is a growing need to standardize quality control (QC) testing procedures. The determination of radiochemical pu...

    Authors: James M. Kelly, Alejandro Amor-Coarasa, Elizabeth Sweeney, Justin J. Wilson, Patrick W. Causey and John W. Babich
    Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:38
    Content type: Research article Published on:

  17. Terbium-155 [T1/2 = 5.32 d, Eγ = 87 keV (32%) 105 keV (25%)] is an interesting radionuclide suitable for single photon emission computed tomography (SPECT) imaging with potential application in the diagnosis of o...

    Authors: C. Favaretto, Z. Talip, F. Borgna, P. V. Grundler, G. Dellepiane, A. Sommerhalder, H. Zhang, R. Schibli, S. Braccini, C. Müller and N. P. van der Meulen
    Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:37
    Content type: Research article Published on:

  18. Prostate-specific membrane antigen is overexpressed in prostate cancer and it is considered a good target for positron emission tomography/computed tomography imaging of primary cancer and recurrent/metastatic...

    Authors: Costantina Maisto, Anna Morisco, Roberta de Marino, Elisabetta Squame, Valentina Porfidia, Laura D’Ambrosio, Daria Di Martino, Paolo Gaballo, Michela Aurilio, Monica Buonanno, Aureliana Esposito, Marco Raddi and Secondo Lastoria
    Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:36
    Content type: Research article Published on:

  19. Nanocolloidal human serum albumin radiolabelled with 99mTc provides a diagnostic radiopharmaceutical for sentinel node lymphoscintigraphy. NanoHSA (Nanotop), a commercially available kit, enables the simple prepa...

    Authors: Ruslan Cusnir, Michel Leresche, Claude Pilloud and Marietta Straub
    Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:35
    Content type: Research article Published on:

  20. This guideline on molar activity (Am) and specific activity (As) focusses on small molecules, peptides and macromolecules radiolabelled for diagnostic and therapeutic applications. In this guideline we describe t...

    Authors: Gert Luurtsema, Verena Pichler, Salvatore Bongarzone, Yann Seimbille, Philip Elsinga, Antony Gee and Johnny Vercouillie
    Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:34
    Content type: Guideline article Published on:

  21. Positron emission tomography (PET) has become an invaluable tool for drug discovery and diagnosis. The positron-emitting radionuclide fluorine-18 is frequently used in PET radiopharmaceuticals due to its advan...

    Authors: Javier Ajenjo, Gianluca Destro, Bart Cornelissen and Véronique Gouverneur
    Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:33
    Content type: Review Published on:

    The Correction to this article has been published in EJNMMI Radiopharmacy and Chemistry 2022 7:1

  23. The Editorial Board of EJNMMI Radiopharmacy and Chemistry releases a biyearly highlight commentary to update the readership on trends in the field of radiopharmaceutical development.

    Authors: Francisco Alves, Inês F. Antunes, Emiliano Cazzola, Frederik Cleeren, Bart Cornelissen, Antonia Denkova, Jonathan Engle, Alain Faivre-Chauvet, Nic Gillings, Jeroen J. M. A. Hendrikx, Amir R. Jalilian, Nicholas P. van der Meulen, Renata Mikolajczak, Oliver C. Neels, Maroor R. A. Pillai, Raymond Reilly…
    Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:31
    Content type: Review Published on:

  24. The aluminium-[18F]fluoride ([18F]AlF) radiolabelling method combines the favourable decay characteristics of fluorine-18 with the convenience and familiarity of metal-based radiochemistry and has been used to pa...

    Authors: Stephen J. Archibald and Louis Allott
    Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:30
    Content type: Review Published on:

    The Correction to this article has been published in EJNMMI Radiopharmacy and Chemistry 2021 6:32

  25. Elevated kidney uptake in insulinoma patients remains a major limitation of radiometallated exendin-derived ligands of the glucagon-like peptide 1 receptor (GLP-1R). Based on the previously published potent GL...

    Authors: Veronika Barbara Felber and Hans-Jürgen Wester
    Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:29
    Content type: Research article Published on:

  26. Fibroblast activation protein (FAP) is overexpressed in the stroma of many types of cancer. [18F]AlF-FAPI-74 is a positron emission tomography tracer with high selectivity for FAP, which has already shown high ac...

    Authors: Sadahiro Naka, Tadashi Watabe, Thomas Lindner, Jens Cardinale, Kenta Kurimoto, Melissa Moore, Mitsuaki Tatsumi, Yuriko Mori, Eku Shimosegawa, Frank Valla Jr., Hiroki Kato and Frederik L. Giesel
    Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:28
    Content type: Methodology Published on:

  27. Patients with chronic kidney disease (CKD) may need to have their radiopharmaceutical dosage adjusted to prevent adverse effects and poor outcomes, but there are few recommendations on radiopharmaceutical dosi...

    Authors: Nanno Schreuder, Iris de Romijn, Pieter L. Jager, Jos G. W. Kosterink and Eugène P. van Puijenbroek
    Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:27
    Content type: Review Published on:

  28. Cancer-associated fibroblasts are found in the stroma of epithelial tumors. They are characterized by overexpression of the fibroblast activation protein (FAP), a serine protease which was already proven as at...

    Authors: Thomas Lindner, Annette Altmann, Frederik Giesel, Clemens Kratochwil, Christian Kleist, Susanne Krämer, Walter Mier, Jens Cardinale, Hans-Ulrich Kauczor, Dirk Jäger, Jürgen Debus and Uwe Haberkorn
    Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:26
    Content type: Research article Published on:

  29. Epidermal growth factor receptors (EGFR) are overexpressed on many head and neck squamous cell carcinoma (HNSCC). Radioimmunotherapy (RIT) with F(ab')2 of the anti-EGFR monoclonal antibody panitumumab labeled wit...

    Authors: Anthony Ku, Misaki Kondo, Zhongli Cai, Jalna Meens, Min Rong Li, Laurie Ailles and Raymond M. Reilly
    Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:25
    Content type: Research article Published on:

  30. [18F]MC225 is a radiotracer for imaging P-glycoprotein (P-gp) function at the blood-brain barrier. The P-gp function can be altered due to different factors, for instance, decreased P-gp function has been describ...

    Authors: Lara Garcia-Varela, Khaled Attia, John Carlo Sembrano, Olivier Jacquet, Inês F. Antunes, Chantal Kwizera, Ton J. Visser, Rudi A. J. O. Dierckx, Philip H. Elsinga and Gert Luurtsema
    Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:24
    Content type: Research article Published on:

  31. [18F]Fluoromisonidazole ([18F]FMISO) and 1-[18F]fluoro-3-((2-((1E,3E)-4-(6-(methylamino)pyridine-3-yl)buta-1,3-dien-1-yl)benzo[d]thiazol-6-yl)oxy)propan-2-ol ([18F]PM-PBB3 or [18F]APN-1607) are clinically used ra...

    Authors: Takayuki Ohkubo, Yusuke Kurihara, Masanao Ogawa, Nobuki Nengaki, Masayuki Fujinaga, Wakana Mori, Katsushi Kumata, Masayuki Hanyu, Kenji Furutsuka, Hiroki Hashimoto, Kazunori Kawamura and Ming-Rong Zhang
    Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:23
    Content type: Research article Published on:

  32. [68Ga]Ga-NeoB is a novel DOTA-coupled Gastrin Releasing Peptide Receptor (GRPR) antagonist with high affinity for GRPR and good in vivo stability. This study aimed at (1) the translation of preclinical results to...

    Authors: Marc Pretze, Laura Reffert, Steffen Diehl, Stefan O. Schönberg, Carmen Wängler, Peter Hohenberger and Björn Wängler
    Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:22
    Content type: Research article Published on:

  33. The radiofluorinated levodopa analogue 6-[18F]F-l-DOPA (3,4-dihydroxy-6-18F-l-phenylalanine) is a commonly employed radiotracer for PET/CT imaging of multiple oncological and neurological indications. An unusuall...

    Authors: Valdemar L. Andersen, Mikkel A. Soerensen, Johan Hygum Dam, Niels Langkjaer, Henrik Petersen, Dirk Andreas Bender, Dan Fugloe and Tri Hien Viet Huynh
    Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:21
    Content type: Research article Published on:

  34. The translocator protein 18 kDa is recognised as an important biomarker for neuroinflammation due to its soaring expression in microglia. This process is common for various neurological disorders. DPA-714 is a...

    Authors: Klaudia A. Cybulska, Vera Bloemers, Lars R. Perk and Peter Laverman
    Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:20
    Content type: Research article Published on:

  35. In the frame of “precision medicine”, the scandium radionuclides have recently received considerable interest, providing personalised adjustment of radiation characteristics to optimize the efficiency of medic...

    Authors: R. Mikolajczak, S. Huclier-Markai, C. Alliot, F. Haddad, D. Szikra, V. Forgacs and P. Garnuszek
    Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:19
    Content type: Review Published on:

  36. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Ângela C. B. Neves, Ivanna Hrynchak, Inês Fonseca, Vítor H. P. Alves, Mariette M. Pereira, Amílcar Falcão and Antero J. Abrunhosa
    Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:18
    Content type: Correction Published on:

    The original article was published in EJNMMI Radiopharmacy and Chemistry 2021 6:11

  38. To the best of our knowledge, manually production of [177Lu]Lu-FAPI radiopharmaceutical derivatives has been only described in literature. In this work, a fully-automated [177Lu]Lu-FAPI synthesis has been well de...

    Authors: Kurtulus Eryilmaz and Benan Kilbas
    Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:16
    Content type: Research article Published on:

    The Correction to this article has been published in EJNMMI Radiopharmacy and Chemistry 2021 6:17

  39. HEPES (4-(2-hydroxyethyl) piperazine-1-ethanesulfonic acid) is a buffer that is used in the radiolabelling of gallium-68 compounds. The beneficial effects of HEPES on molar activity in bioconjugates have been ...

    Authors: Jannie le Roux, Janke Kleynhans and Sietske Rubow
    Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:15
    Content type: Letter to the Editor Published on:

  40. The stability of precursors and reagents is of utmost importance for developing a robust radiolabelling method that provides high and constant radiochemical yield and radiochemical purity.

    Authors: Antonella Iudicello, Filippo Genovese, Valentina Di Iorio, Gianfranco Cicoria and Stefano Boschi
    Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:14
    Content type: Research article Published on:

  41. The Editorial Board of EJNMMI Radiopharmacy and Chemistry releases a biyearly highlight commentary to update the readership on trends in the field of radiopharmaceutical development.

    Authors: Silvio Aime, Mohammed Al-Qahtani, Martin Behe, Guy Bormans, Giuseppe Carlucci, Jean N. DaSilva, Clemens Decristoforo, Adriano Duatti, Philip H. Elsinga, Klaus Kopka, Xiang-Guo Li, Zhibo Liu, Robert H. Mach, Oskar Middel, Jan Passchier, Marianne Patt…
    Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:13
    Content type: Review Published on:

  42. There is a need to develop new and more potent radiofluorinated peptide and their hybrid conjugates for multiple-receptors targeting properties that overexpress on many cancers.

    Authors: I. Al Jammaz, B. Al-Otaibi, Y. Al-Malki, A. Abousekhrah and S. M. Okarvi
    Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:12
    Content type: Research article Published on:

  43. The neurotracer 6-[18F]FDOPA has been, for many years, a powerful tool in PET imaging of neuropsychiatric diseases, movement disorders and brain malignancies. More recently, it also demonstrated good results in t...

    Authors: Ângela C. B. Neves, Ivanna Hrynchak, Inês Fonseca, Vítor H. P. Alves, Mariette M. Pereira, Amílcar Falcão and Antero J. Abrunhosa
    Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:11
    Content type: Review Published on:

    The Correction to this article has been published in EJNMMI Radiopharmacy and Chemistry 2021 6:18

  44. To investigate whether modifications of prostate-specific membrane antigen (PSMA)-targeted radiolabeled urea-based inhibitors could reduce salivary gland uptake and thus improve tumor-to-salivary gland ratios,...

    Authors: Veronika Barbara Felber, Manuel Amando Valentin and Hans-Jürgen Wester
    Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:10
    Content type: Research article Published on:

  45. Increased vascular permeability is an early sign of vascular damage and can be measured with the transcapillary escape rate of albumin (TERalb). Although TERalb has a multi-exponential kinetic model, most publish...

    Authors: Youssef Chahid, Nienke M. G. Rorije, Soufian el Boujoufi, Ron A. A. Mathôt, Liffert Vogt and Hein J. Verberne
    Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:9
    Content type: Research article Published on:

  46. This guideline on current good radiopharmacy practice (cGRPP) for small-scale preparation of radiopharmaceuticals represents the view of the Radiopharmacy Committee of the European Association of Nuclear Medic...

    Authors: Nic Gillings, Olaug Hjelstuen, Jim Ballinger, Martin Behe, Clemens Decristoforo, Philip Elsinga, Valentina Ferrari, Petra Kolenc Peitl, Jacek Koziorowski, Peter Laverman, Thomas L. Mindt, Oliver Neels, Meltem Ocak, Marianne Patt and Sergio Todde
    Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:8
    Content type: Guideline article Published on:

  47. The understanding of the role of different immune cell subsets that infiltrate tumors can help researchers in developing new targeted immunotherapies to reactivate or reprogram them against cancer. In addition...

    Authors: Filippo Galli, Michela Varani, Chiara Lauri, Guido Gentiloni Silveri, Livia Onofrio and Alberto Signore
    Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:7
    Content type: Review Published on:

  48. Lead-212 (212Pb, t1/2 = 10.6 h) and lead-203 (203Pb, t1/2 = 51.9 h) are an element-equivalent, or a matched theranostic radioisotope pair that show great potential for application in targeted radionuclide therapy...

    Authors: Brooke L. McNeil, Andrew K. H. Robertson, Winnie Fu, Hua Yang, Cornelia Hoehr, Caterina F. Ramogida and Paul Schaffer
    Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:6
    Content type: Research article Published on:

  49. The Editorial Board of EJNMMI Radiopharmacy and Chemistry releases a biyearly highlight commentary to describe trends in the field.

    Authors: Mohammed Al-Qahtani, Martin Behe, Guy Bormans, Giuseppe Carlucci, Jean Dasilva, Clemens Decristoforo, Philip H. Elsinga, Klaus Kopka, Xiang-Guo Li, Robert Mach, Oskar Middel, Jan Passchier, Marianne Patt, Ivan Penuelas, Ana Rey, Peter J. H. Scott…
    Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:5
    Content type: Review Published on:

  50. The radiohybrid (rh) prostate-specific membrane antigen (PSMA)-targeted ligand [18F]Ga-rhPSMA-7 has previously been clinically assessed and demonstrated promising results for PET-imaging of prostate cancer. The l...

    Authors: Alexander Wurzer, Daniel Di Carlo, Michael Herz, Antonia Richter, Stephanie Robu, Ralf Schirrmacher, Alba Mascarin, Wolfgang Weber, Matthias Eiber, Markus Schwaiger and Hans-Juergen Wester
    Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:4
    Content type: Research article Published on:
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