Research article
[18F]AV1451 is a commonly used radiotracer for imaging tau deposits in Alzheimer’s disease (AD) and related non-AD tauopathies. Existing radiosyntheses of [18F]AV1451 require complex purifications to provide dose...
EJNMMI Radiopharmacy and Chemistry 2017 2:7
Published on: 6 June 2017
Review
Oncological pretargeting has been implemented and tested in several different ways in preclinical models and clinical trials over more than 30 years. Despite highly promising results, pretargeting has not achi...
EJNMMI Radiopharmacy and Chemistry 2017 2:6
Published on: 6 June 2017
Research article
Radiotheragnostics makes use of the same molecular targeting vectors, labeled either with a diagnostic or therapeutic radionuclide, ideally of the same chemical element. The matched pair of scandium radionucli...
EJNMMI Radiopharmacy and Chemistry 2017 2:5
Published on: 2 June 2017
Research article
The somatostatin receptor subtype 2 (sstr2) is expressed on a majority of luminal breast cancers, however SPECT and scintigraphy imaging with agonistic sstr2 probes has been sub-optimal. High affinity antagoni...
EJNMMI Radiopharmacy and Chemistry 2017 2:4
Published on: 17 April 2017
Research article
Radiolabeled phosphatidylserine (PS)-binding peptides represent an innovative strategy for molecular imaging of apoptosis and thrombus. The hexapeptide PGDLSR was described as a selective and high affinity lig...
EJNMMI Radiopharmacy and Chemistry 2017 2:3
Published on: 7 February 2017
Research
The chemokine receptor 4 (CXCR4) is an important molecular target for both visualization and therapy of tumors. The aim of the present study was the synthesis and preclinical evaluation of a 64Cu-labeled, CXCR4-t...
EJNMMI Radiopharmacy and Chemistry 2017 2:2
Published on: 19 January 2017
Editorial
EJNMMI Radiopharmacy and Chemistry 2017 2:1
Published on: 18 January 2017
Research
αVβ3, αVβ5 and α5β1 integrins are known to be involved in carcinogenesis and are overexpressed in many types of tumours compared to healthy tissues; thereby they have been selected as promising therapeutic target...
EJNMMI Radiopharmacy and Chemistry 2016 1:16
Published on: 25 October 2016
Research
Fast implementation of positron emission tomography (PET) into clinical and preclinical studies highly demands automated synthesis for the preparation of PET radiopharmaceuticals in a safe and reproducible man...
EJNMMI Radiopharmacy and Chemistry 2016 1:15
Published on: 10 October 2016
Research
Bisphosphonates have a high adsorption on calcified tissues and are commonly used in the treatment of bone disorder diseases. Conjugates of bisphosphonates with macrocyclic chelators open new possibilities in ...
EJNMMI Radiopharmacy and Chemistry 2016 1:14
Published on: 23 September 2016
Review
Positron Emission Tomography (PET), as a non-invasive translatable imaging technology, can be incorporated into various stages of the CNS drug discovery process to provide valuable information for key preclini...
EJNMMI Radiopharmacy and Chemistry 2016 1:13
Published on: 13 September 2016
Editorial
EJNMMI Radiopharmacy and Chemistry 2016 1:12
Published on: 22 July 2016
Meeting abstracts
OP03 Selective extraction of medically-related radionuclides from proton-irradiated thorium targets
EJNMMI Radiopharmacy and Chemistry 2016 1(Suppl 1):10
Published on: 17 June 2016
This article is part of a Supplement: Volume 1 Supplement 1
Review
Traditional nuclear medicine ligands were designed to target cellular receptors or transporters with a binding pocket and a defined structure–activity relationship. More recently, tracers have been developed t...
EJNMMI Radiopharmacy and Chemistry 2016 1:11
Published on: 2 June 2016
Research
213Bismuth (213Bi, T1/2 = 45.6 min) is one of the most frequently used α-emitters in cancer research. High specific activity radioligands are required for peptide receptor radionuclide...
EJNMMI Radiopharmacy and Chemistry 2016 1:9
Published on: 14 May 2016
Research
Recently, 44Sc (T1/2 = 3.97 h, Eβ+ av = 632 keV, I = 94.3 %) has emerged as an attractive radiometal candidate for PET imaging using DOTA-functionalized biomolecules. The aim of this st...
EJNMMI Radiopharmacy and Chemistry 2016 1:8
Published on: 5 May 2016
Research
6-[18F]Fluoro-L-3,4-dihydroxyphenylalanine (FDOPA) is a frequently used radiopharmaceutical for detecting neuroendocrine and brain tumors and for the differential diagnosis of Parkinson’s disease. To meet the dem...
EJNMMI Radiopharmacy and Chemistry 2016 1:7
Published on: 4 April 2016
Research
Typically, metal-based radiopharmaceuticals are synthesized in aqueous solutions with no or low ethanol content. Labeling yields are defined by temperature, period of labeling, amount of precursor, pH etc. As ...
EJNMMI Radiopharmacy and Chemistry 2016 1:6
Published on: 1 April 2016
Letter to the Editor
149Tb represents a powerful alternative to currently used α-emitters: the relatively short half-life (T1/2 = 4.1 h), low α-energy (3.97 MeV, Iα = 16.7 %), absence of α-emitting daughters ...
EJNMMI Radiopharmacy and Chemistry 2016 1:5
Published on: 28 March 2016
Editorial
EJNMMI Radiopharmacy and Chemistry 2016 1:2
Published on: 21 March 2016
Position paper
This is a position paper of the Radiopharmacy Committee of the EANM (European Association of Nuclear Medicine) addressing toxicology studies for application of new diagnostic and therapeutic radiopharmaceutica...
EJNMMI Radiopharmacy and Chemistry 2016 1:1
Published on: 21 March 2016
Research
The widespread acceptance and application of 68Ga-PET depends on our ability to develop radiopharmaceuticals that can be prepared in a convenient and suitable manner. A kit-type labelling protocol provides such c...
EJNMMI Radiopharmacy and Chemistry 2016 1:4
Published on: 21 March 2016
Research
Phosphodiesterase 10A (PDE10A) is an important regulator of nigrostriatal dopamine (DA) neurotransmission. However, little is known on the effect of alterations in DA neurotransmission on PDE10A availability. ...
EJNMMI Radiopharmacy and Chemistry 2016 1:3
Published on: 21 March 2016
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