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Articles
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Citation: EJNMMI Radiopharmacy and Chemistry 2022 7:1
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A suitable time point for quantifying the radiochemical purity of 225Ac-labeled radiopharmaceuticals
As 225Ac-labeled radiopharmaceuticals continue to show promise as targeted alpha therapeutics, there is a growing need to standardize quality control (QC) testing procedures. The determination of radiochemical pu...
Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:38 -
Cyclotron production and radiochemical purification of terbium-155 for SPECT imaging
Terbium-155 [T1/2 = 5.32 d, Eγ = 87 keV (32%) 105 keV (25%)] is an interesting radionuclide suitable for single photon emission computed tomography (SPECT) imaging with potential application in the diagnosis of o...
Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:37 -
On site production of [18F]PSMA-1007 using different [18F]fluoride activities: practical, technical and economical impact
Prostate-specific membrane antigen is overexpressed in prostate cancer and it is considered a good target for positron emission tomography/computed tomography imaging of primary cancer and recurrent/metastatic...
Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:36 -
An investigation of aspects of radiochemical purity of 99mTc-labelled human serum albumin nanocolloid
Nanocolloidal human serum albumin radiolabelled with 99mTc provides a diagnostic radiopharmaceutical for sentinel node lymphoscintigraphy. NanoHSA (Nanotop), a commercially available kit, enables the simple prepa...
Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:35 -
EANM guideline for harmonisation on molar activity or specific activity of radiopharmaceuticals: impact on safety and imaging quality
This guideline on molar activity (Am) and specific activity (As) focusses on small molecules, peptides and macromolecules radiolabelled for diagnostic and therapeutic applications. In this guideline we describe t...
Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:34 -
Closing the gap between 19F and 18F chemistry
Positron emission tomography (PET) has become an invaluable tool for drug discovery and diagnosis. The positron-emitting radionuclide fluorine-18 is frequently used in PET radiopharmaceuticals due to its advan...
Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:33 -
Correction to: The aluminium-[18F]fuoride revolution: simple radiochemistry with a big impact for radiolabelled biomolecules
Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:32 -
Highlight selection of radiochemistry and radiopharmacy developments by editorial board
The Editorial Board of EJNMMI Radiopharmacy and Chemistry releases a biyearly highlight commentary to update the readership on trends in the field of radiopharmaceutical development.
Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:31 -
The aluminium-[18F]fluoride revolution: simple radiochemistry with a big impact for radiolabelled biomolecules
The aluminium-[18F]fluoride ([18F]AlF) radiolabelling method combines the favourable decay characteristics of fluorine-18 with the convenience and familiarity of metal-based radiochemistry and has been used to pa...
Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:30 -
Small peptide-based GLP-1R ligands: an approach to reduce the kidney uptake of radiolabeled GLP-1R-targeting agents?
Elevated kidney uptake in insulinoma patients remains a major limitation of radiometallated exendin-derived ligands of the glucagon-like peptide 1 receptor (GLP-1R). Based on the previously published potent GL...
Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:29 -
One-pot and one-step automated radio-synthesis of [18F]AlF-FAPI-74 using a multi purpose synthesizer: a proof-of-concept experiment
Fibroblast activation protein (FAP) is overexpressed in the stroma of many types of cancer. [18F]AlF-FAPI-74 is a positron emission tomography tracer with high selectivity for FAP, which has already shown high ac...
Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:28 -
Safe use of radiopharmaceuticals in patients with chronic kidney disease: a systematic review
Patients with chronic kidney disease (CKD) may need to have their radiopharmaceutical dosage adjusted to prevent adverse effects and poor outcomes, but there are few recommendations on radiopharmaceutical dosi...
Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:27 -
18F-labeled tracers targeting fibroblast activation protein
Cancer-associated fibroblasts are found in the stroma of epithelial tumors. They are characterized by overexpression of the fibroblast activation protein (FAP), a serine protease which was already proven as at...
Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:26 -
Dose predictions for [177Lu]Lu-DOTA-panitumumab F(ab′)2 in NRG mice with HNSCC patient-derived tumour xenografts based on [64Cu]Cu-DOTA-panitumumab F(ab′)2 – implications for a PET theranostic strategy
Epidermal growth factor receptors (EGFR) are overexpressed on many head and neck squamous cell carcinoma (HNSCC). Radioimmunotherapy (RIT) with F(ab')2 of the anti-EGFR monoclonal antibody panitumumab labeled wit...
Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:25 -
A new approach to produce [18F]MC225 via one-step synthesis, a PET radiotracer for measuring P-gp function
[18F]MC225 is a radiotracer for imaging P-glycoprotein (P-gp) function at the blood-brain barrier. The P-gp function can be altered due to different factors, for instance, decreased P-gp function has been describ...
Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:24 -
Automated radiosynthesis of two 18F-labeled tracers containing 3-fluoro-2-hydroxypropyl moiety, [18F]FMISO and [18F]PM-PBB3, via [18F]epifluorohydrin
[18F]Fluoromisonidazole ([18F]FMISO) and 1-[18F]fluoro-3-((2-((1E,3E)-4-(6-(methylamino)pyridine-3-yl)buta-1,3-dien-1-yl)benzo[d]thiazol-6-yl)oxy)propan-2-ol ([18F]PM-PBB3 or [18F]APN-1607) are clinically used ra...
Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:23 -
GMP-compliant production of [68Ga]Ga-NeoB for positron emission tomography imaging of patients with gastrointestinal stromal tumor
[68Ga]Ga-NeoB is a novel DOTA-coupled Gastrin Releasing Peptide Receptor (GRPR) antagonist with high affinity for GRPR and good in vivo stability. This study aimed at (1) the translation of preclinical results to...
Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:22 -
GMP production of 6-[18F]Fluoro-l-DOPA for PET/CT imaging by different synthetic routes: a three center experience
The radiofluorinated levodopa analogue 6-[18F]F-l-DOPA (3,4-dihydroxy-6-18F-l-phenylalanine) is a commonly employed radiotracer for PET/CT imaging of multiple oncological and neurological indications. An unusuall...
Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:21 -
Optimised GMP-compliant production of [18F]DPA-714 on the Trasis AllinOne module
The translocator protein 18 kDa is recognised as an important biomarker for neuroinflammation due to its soaring expression in microglia. This process is common for various neurological disorders. DPA-714 is a...
Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:20 -
Production of scandium radionuclides for theranostic applications: towards standardization of quality requirements
In the frame of “precision medicine”, the scandium radionuclides have recently received considerable interest, providing personalised adjustment of radiation characteristics to optimize the efficiency of medic...
Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:19 -
Correction to: Advances in the automated synthesis of 6-[18F]Fluoro-L-DOPA
An amendment to this paper has been published and can be accessed via the original article.
Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:18 -
Correction to: Fully-automated synthesis of 177Lu labelled FAPI derivatives on the module modular lab-Eazy
Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:17 -
Fully-automated synthesis of 177Lu labelled FAPI derivatives on the module modular lab-Eazy
To the best of our knowledge, manually production of [177Lu]Lu-FAPI radiopharmaceutical derivatives has been only described in literature. In this work, a fully-automated [177Lu]Lu-FAPI synthesis has been well de...
Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:16 -
The use of HEPES-buffer in the production of gallium-68 radiopharmaceuticals – time to reconsider strict pharmacopoeial limits?
HEPES (4-(2-hydroxyethyl) piperazine-1-ethanesulfonic acid) is a buffer that is used in the radiolabelling of gallium-68 compounds. The beneficial effects of HEPES on molar activity in bioconjugates have been ...
Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:15 -
An HPLC and UHPLC-HRMS approach to study PSMA-11 instability in aqueous solution
The stability of precursors and reagents is of utmost importance for developing a robust radiolabelling method that provides high and constant radiochemical yield and radiochemical purity.
Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:14 -
Highlight selection of radiochemistry and radiopharmacy developments by editorial board
The Editorial Board of EJNMMI Radiopharmacy and Chemistry releases a biyearly highlight commentary to update the readership on trends in the field of radiopharmaceutical development.
Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:13 -
Fast Fluorine-18 labeling and preclinical evaluation of novel Mucin1 and its Folate hybrid peptide conjugate for targeting breast carcinoma
There is a need to develop new and more potent radiofluorinated peptide and their hybrid conjugates for multiple-receptors targeting properties that overexpress on many cancers.
Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:12 -
Advances in the automated synthesis of 6-[18F]Fluoro-L-DOPA
The neurotracer 6-[18F]FDOPA has been, for many years, a powerful tool in PET imaging of neuropsychiatric diseases, movement disorders and brain malignancies. More recently, it also demonstrated good results in t...
Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:11 -
Design of PSMA ligands with modifications at the inhibitor part: an approach to reduce the salivary gland uptake of radiolabeled PSMA inhibitors?
To investigate whether modifications of prostate-specific membrane antigen (PSMA)-targeted radiolabeled urea-based inhibitors could reduce salivary gland uptake and thus improve tumor-to-salivary gland ratios,...
Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:10 -
Transcapillary escape rate of 125I-albumin in relation to timing of blood sampling: the need for standardization
Increased vascular permeability is an early sign of vascular damage and can be measured with the transcapillary escape rate of albumin (TERalb). Although TERalb has a multi-exponential kinetic model, most publish...
Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:9 -
Guideline on current good radiopharmacy practice (cGRPP) for the small-scale preparation of radiopharmaceuticals
This guideline on current good radiopharmacy practice (cGRPP) for small-scale preparation of radiopharmaceuticals represents the view of the Radiopharmacy Committee of the European Association of Nuclear Medic...
Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:8 -
Immune cell labelling and tracking: implications for adoptive cell transfer therapies
The understanding of the role of different immune cell subsets that infiltrate tumors can help researchers in developing new targeted immunotherapies to reactivate or reprogram them against cancer. In addition...
Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:7 -
Production, purification, and radiolabeling of the 203Pb/212Pb theranostic pair
Lead-212 (212Pb, t1/2 = 10.6 h) and lead-203 (203Pb, t1/2 = 51.9 h) are an element-equivalent, or a matched theranostic radioisotope pair that show great potential for application in targeted radionuclide therapy...
Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:6 -
Highlight selection of radiochemistry and radiopharmacy developments by editorial board (January–June 2020)
The Editorial Board of EJNMMI Radiopharmacy and Chemistry releases a biyearly highlight commentary to describe trends in the field.
Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:5 -
Automated synthesis of [18F]Ga-rhPSMA-7/ -7.3: results, quality control and experience from more than 200 routine productions
The radiohybrid (rh) prostate-specific membrane antigen (PSMA)-targeted ligand [18F]Ga-rhPSMA-7 has previously been clinically assessed and demonstrated promising results for PET-imaging of prostate cancer. The l...
Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:4 -
Synthesis of DOTA-pyridine chelates for 64Cu coordination and radiolabeling of αMSH peptide
64Cu is one of the few radioisotopes that can be used for both imaging and therapy, enabling theranostics with identical chemical composition. Development of stable chelators is essential to harness the potentia....
Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:3 -
Implementation and validation of an in-house combined fluorescein/media-fill test to qualify radiopharmacy operators
The purpose of this work was to design, validate and implement a media-fill test combined with fluorescein (MFT-F) for the specific qualification and training of radiopharmacy operators, in accordance with Uni...
Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:2 -
Multi-curie production of gallium-68 on a biomedical cyclotron and automated radiolabelling of PSMA-11 and DOTATATE
With increasing clinical demand for gallium-68, commercial germanium-68/gallium-68 ([68Ge]Ge/[68Ga]Ga) generators are incapable of supplying sufficient amounts of the short-lived daughter isotope. In this study, ...
Citation: EJNMMI Radiopharmacy and Chemistry 2021 6:1 -
Fully-automated production of [68Ga]Ga-FAPI-46 for clinical application
[68Ga]Ga-FAPI-46 is a promising radiopharmaceutical for in vivo detection of the fibroblast activation protein by positron emission tomography. Until now, the synthesis of [68Ga]Ga-FAPI-46 has been only performed...
Citation: EJNMMI Radiopharmacy and Chemistry 2020 5:31 -
A simple and efficient automated microvolume radiosynthesis of [18F]Florbetaben
Current automated radiosynthesizers are generally optimized for producing large batches of PET tracers. Preclinical imaging studies, however, often require only a small portion of a regular batch, which cannot...
Citation: EJNMMI Radiopharmacy and Chemistry 2020 5:30 -
Effect of the versatile bifunctional chelator AAZTA5 on the radiometal labelling properties and the in vitro performance of a gastrin releasing peptide receptor antagonist
Gastrin Releasing Peptide receptor (GRPr)-based radioligands have shown great promise for diagnostic imaging of GRPr-positive cancers, such as prostate and breast.
Citation: EJNMMI Radiopharmacy and Chemistry 2020 5:29 -
68Ga, 44Sc and 177Lu-labeled AAZTA5-PSMA-617: synthesis, radiolabeling, stability and cell binding compared to DOTA-PSMA-617 analogues
The AAZTA chelator and in particular its bifunctional derivative AAZTA5 was recently investigated to demonstrate unique capabilities to complex diagnostic and therapeutic trivalent radiometals under mild conditio...
Citation: EJNMMI Radiopharmacy and Chemistry 2020 5:28 -
Improved non-invasive positron emission tomographic imaging of chemotherapy-induced tumor cell death using Zirconium-89-labeled APOMAB®
The chimeric monoclonal antibody (mAb) chDAB4 (APOMAB®) targets the Lupus associated (La)/Sjögren Syndrome-B (SSB) antigen, which is over-expressed in tumors but only becomes available for antibody binding in ...
Citation: EJNMMI Radiopharmacy and Chemistry 2020 5:27 -
Fully automated radiosynthesis of [18F]LBT999 on TRACERlab FXFN and AllinOne modules, a PET radiopharmaceutical for imaging the dopamine transporter in human brain
Fluorine labelled 8-((E)-4-fluoro-but-2-enyl)-3β-p-tolyl-8-aza-bicyclo[3.2.1]octane-2β-carboxylic acid methyl ester ([18F]LBT999) is a selective radioligand for the in vivo neuroimaging and quantification of the ...
Citation: EJNMMI Radiopharmacy and Chemistry 2020 5:26 -
Cyclotron-based production of 68Ga, [68Ga]GaCl3, and [68Ga]Ga-PSMA-11 from a liquid target
To optimize the direct production of 68Ga on a cyclotron, via the 68Zn(p,n)68Ga reaction using a liquid cyclotron target. We Investigated the yield of cyclotron-produced 68Ga, extraction of [68Ga]GaCl3 and subseq...
Citation: EJNMMI Radiopharmacy and Chemistry 2020 5:25 -
Use of 55 PET radiotracers under approval of a Radioactive Drug Research Committee (RDRC)
In the US, EU and elsewhere, basic clinical research studies with positron emission tomography (PET) radiotracers that are generally recognized as safe and effective (GRASE) can often be conducted under instit...
Citation: EJNMMI Radiopharmacy and Chemistry 2020 5:24 -
Automated synthesis of 18F radiolabelled indole containing Oncrasin-like molecules; a comparison of iodonium salts and boronic ester chemistry
Oncrasin-1 is a small molecule which was identified from a screen of KRAS mutant cancer cells and has shown specificity for KRAS mutant cell killing. We aimed to develop a radiolabelled form of Oncrasin-1 to e...
Citation: EJNMMI Radiopharmacy and Chemistry 2020 5:23 -
Radioimmunotherapy of PANC-1 human pancreatic cancer xenografts in NOD/SCID or NRG mice with Panitumumab labeled with Auger electron emitting, 111In or β-particle emitting, 177Lu
Epidermal growth factor receptors (EGFR) are overexpressed on > 90% of pancreatic cancers (PnCa) and represent an attractive target for the development of novel therapies, including radioimmunotherapy (RIT). O...
Citation: EJNMMI Radiopharmacy and Chemistry 2020 5:22 -
Automated, cassette-based isolation and formulation of high-purity [61Cu]CuCl2 from solid Ni targets
A need for improved, cassette-based automation of 61Cu separation from irradiated Ni targets was identified given the growing interest in theranostics, and generally lengthy separation chemistries for 64Cu/64Ni, ...
Citation: EJNMMI Radiopharmacy and Chemistry 2020 5:21
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