Table 1 Clinically approved ^99mTc-labeled nanoparticles and microparticles by SPECT imaging

Sulfur colloid

Technecoll (US)

100–300 nm

Lymph node, bone marrow, GI, liver, and spleen imaging

Thakor et al. 2016; Palestro et al. 2006)

Albumin colloid

Nanocoll (EU)

6–80 nm

Lymph node, inflammation, melanoma, and prostate imaging

Thakor et al. 2016; Gommans et al. 2009)

SnF₂ colloid

Hepatate (France)

 < 200 nm

Lymph node, GI, liver, and spleen imaging

Thakor et al. 2016; McClelland et al. 2003)

Re₂S₇ colloid

Nanocis (EU)

10–70 nm

Lymph node, GI, melanoma, and prostate imaging

Thakor et al. 2016; Tsopelas 2014)

Albumin colloid

Senti-Scint

100–600 nm

Lymph node imaging of breast

Thakor et al. 2016; Kim et al. 2001)

Tilmanocept

Lymphoseek

7 nm

Lymphatic mapping and sentinel lymph node localization

Surasi et al. 2015)

Albumin macroaggregates

Macroaggregated albumin (MAA)

10–90 microns

Lung perfusion imaging

Hunt et al. 2006; Hung et al. 2000)