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Table 1 Clinically approved 99mTc-labeled nanoparticles and microparticles by SPECT imaging

From: Radiolabeled nanomaterials for biomedical applications: radiopharmacy in the era of nanotechnology

Type Trade name Particle size Evaluated applications References
Sulfur colloid Technecoll (US) 100–300 nm Lymph node, bone marrow, GI, liver, and spleen imaging Thakor et al. 2016; Palestro et al. 2006)
Albumin colloid Nanocoll (EU) 6–80 nm Lymph node, inflammation, melanoma, and prostate imaging Thakor et al. 2016; Gommans et al. 2009)
SnF2 colloid Hepatate (France)  < 200 nm Lymph node, GI, liver, and spleen imaging Thakor et al. 2016; McClelland et al. 2003)
Re2S7 colloid Nanocis (EU) 10–70 nm Lymph node, GI, melanoma, and prostate imaging Thakor et al. 2016; Tsopelas 2014)
Albumin colloid Senti-Scint 100–600 nm Lymph node imaging of breast Thakor et al. 2016; Kim et al. 2001)
Tilmanocept Lymphoseek 7 nm Lymphatic mapping and sentinel lymph node localization Surasi et al. 2015)
Albumin macroaggregates Macroaggregated albumin (MAA) 10–90 microns Lung perfusion imaging Hunt et al. 2006; Hung et al. 2000)