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Table 1 Biodistribution of [11C]PK68 in mice (n = 3, mean ± SD)

From: Synthesis of [11C]carbonyl-labeled cyclohexyl (5-(2-acetamidobenzo[d]thiazol-6-yl)-2-methylpyridin-3-yl)carbamate ([11C-carbonyl]PK68) as a potential PET tracer for receptor-interacting protein 1 kinase

Tissue Time after the injection (min)
1 5 15 30 60
Blood 2.4 ± 0.3 1.3 ± 0.2 1.1 ± 0.1 0.8 ± 0.1 0.5 ± 0.1
Heart 7.6 ± 0.3 2.8 ± 0.3 2.1 ± 0.3 1.3 ± 0.1 0.7 ± 0.1
Lung 5.2 ± 0.2 2.6 ± 0.2 2.1 ± 0.3 1.5 ± 0.2 0.8 ± 0.1
Liver 8.0 ± 0.8 17.2 ± 0.7 15.6 ± 0.8 10.7 ± 0.3 6.0 ± 0.2
Pancreas 3.4 ± 0.2 2.7 ± 0.3 2.1 ± 0.3 1.4 ± 0.1 0.8 ± 0.1
Spleen 1.5 ± 0.2 1.6 ± 0.1 1.4 ± 0.2 0.9 ± 0.0 0.5 ± 0.1
Kidney 10.3 ± 0.5 9.9 ± 0.4 7.7 ± 1.0 6.2 ± 0.6 3.2 ± 0.1
Adrenals 6.2 ± 2.7 4.0 ± 0.5 3.3 ± 0.5 2.1 ± 0.8 1.2 ± 0.1
Stomach 1.2 ± 0.2 2.0 ± 0.1 4.0 ± 1.2 4.7 ± 1.0 7.2 ± 2.4
Small intestine 1.8 ± 0.1 3.3 ± 0.1 9.8 ± 3.1 16.7 ± 1.4 27.7 ± 3.0
Large intestine 0.7 ± 0.1 0.9 ± 0.1 1.4 ± 0.3 1.7 ± 0.4 2.6 ± 0.6
Testis 0.3 ± 0.1 0.3 ± 0.0 0.3 ± 0.0 0.3 ± 0.0 0.2 ± 0.0
Muscle 1.9 ± 0.3 1.1 ± 0.1 0.8 ± 0.1 0.6 ± 0.1 0.3 ± 0.0
Brain 0.6 ± 0.0 0.4 ± 0.0 0.3 ± 0.0 0.2 ± 0.0 0.1 ± 0.0
  1. Radioactivity is expressed as %ID/g