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EJNMMI Radiopharmacy and Chemistry
Scheme 1. | EJNMMI Radiopharmacy and Chemistry

Scheme 1.

From: Synthesis of [11C]carbonyl-labeled cyclohexyl (5-(2-acetamidobenzo[d]thiazol-6-yl)-2-methylpyridin-3-yl)carbamate ([11C-carbonyl]PK68) as a potential PET tracer for receptor-interacting protein 1 kinase

Scheme 1.

Chemical synthesis. Reagents and Conditions: a bis(pinacolato)diboron, Pd(dppf)2⋅CH2Cl2, K2CO3, 1,4-dioxane, reflux, 10 h; b Acetylchloride, Et3N, DMAP, CH2Cl2, room temperature, overnight, for 9a; Boc2O, Et3N, DMAP, CH2Cl2, room temperature, overnight, for 9b; c cyclohexanol, DMAP, THF, 0 °C, 3 h; d KN(TMS)2, toluene, 2-methyl-3-amino-5-bromopyridine in THF, 0 °C, 0.5 h; e Pd(Ph3P)4, K2CO3, 1,4-dioxane + H2O, reflux, 12 h; f 2 mol/L HCl, CH3OH, 60 °C, overnight

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