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EJNMMI Radiopharmacy and Chemistry

Table 4 Radiochemical speciation of hydrophilic impurities in [99mTc]Tc-NanoHSA

From: An investigation of aspects of radiochemical purity of 99mTc-labelled human serum albumin nanocolloid

 

Sep-Pak® fraction A

MEK

0.9% NaCl

% [99mTc]TcO4−

% [99mTc]TcO2

% polar impurities

t0*

49.4 ± 8.2

24.1 ± 8.4

75.9 ± 8.4

+ 30 min#

53.4 ± 22.7

20.1 ± 7.2

79.9 ± 7.2

+ 60 min#

48.0 ± 16.9

25.7 ± 12.4

74.3 ± 12.4

  1. Determined in fraction A, containing hydrophilic impurities not retained on the Sep-Pak® cartridge, with TLC SG-60 stationary phase
  2. *n = 3 experimental replicates
  3. #n = 2 experimental replicates
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