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Table 4 Radiochemical speciation of hydrophilic impurities in [99mTc]Tc-NanoHSA

From: An investigation of aspects of radiochemical purity of 99mTc-labelled human serum albumin nanocolloid

  Sep-Pak® fraction A
MEK 0.9% NaCl
% [99mTc]TcO4 % [99mTc]TcO2 % polar impurities
t0* 49.4 ± 8.2 24.1 ± 8.4 75.9 ± 8.4
+ 30 min# 53.4 ± 22.7 20.1 ± 7.2 79.9 ± 7.2
+ 60 min# 48.0 ± 16.9 25.7 ± 12.4 74.3 ± 12.4
  1. Determined in fraction A, containing hydrophilic impurities not retained on the Sep-Pak® cartridge, with TLC SG-60 stationary phase
  2. *n = 3 experimental replicates
  3. #n = 2 experimental replicates