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EJNMMI Radiopharmacy and Chemistry
Fig. 3 | EJNMMI Radiopharmacy and Chemistry

Fig. 3

From: Highlight selection of radiochemistry and radiopharmacy developments by editorial board

Fig. 3

Schematic overview of convential IgG-radioimmunotherapy (IgG-RIT) and 2-step IgG-pretargeted radioimmunotherapy (IgG-PRIT), compared to self assembling and disassembling pretargeted radioimmunotherapy (SADA-PRIT). Each P53-SADA-BsAb monomer consists out of three domains: an antitumor domain (orange), an anti-DOTA domain (blue), and a SADA domain (green). Self-assembled tetramers disassemble into monomers that are rapidly cleared from circulation

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