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Table 3 Stability of [18F]AlF-FAPI-74 for each formulation solution

From: One-pot and one-step automated radio-synthesis of [18F]AlF-FAPI-74 using a multi purpose synthesizer: a proof-of-concept experiment

Formulation solution

Elapsed time after synthesis (hr)

Batch

0 (EOS)

2

3

4

Radiochemical purity (%)

Saline

    

No. 1

98

96

79

54

No. 2

97

96

94

89

Saline containing 10 mg ascorbic acid and 90 mg sodium ascorbate (pH 5.0)

98

97

96

95

Saline containing 100 mg sodium ascorbate

98

97

97

96

Commercially available phosphate buffered saline (pH 7.4)

98

96

96

95

10 mM phosphate buffered saline (pH 6.7)

98

96

95

89

Commercially available phosphate buffered saline (pH 7.4) containing 100 mg sodium ascorbate

98

97

97

97

10 mM phosphate buffered saline (pH 6.7) containing 100 mg sodium ascorbate

    

No. 1

98

97

97

97

No. 2

98

97

97

97

No. 3

98

97

97

97

  1. EOS, end of synthesis