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EJNMMI Radiopharmacy and Chemistry
Fig. 4 | EJNMMI Radiopharmacy and Chemistry

Fig. 4

From: One-pot and one-step automated radio-synthesis of [18F]AlF-FAPI-74 using a multi purpose synthesizer: a proof-of-concept experiment

Fig. 4

HPLC chromatograms of [18F]AlF-FAPI-74 with 10 mM phosphate buffered saline (pH 6.7) containing 100 mg sodium ascorbate as a formulation solution at the end of synthesis (EOS). a The typical radio-chromatogram of [18F]AlF-FAPI-74 solution. A similar chromatogram was shown in other formulation solutions and its radiochemical purity was ≥ 97%. b The typical ultraviolet (UV)-chromatogram (λ = 264 nm) of [18F]AlF-FAPI-74 solution. In the chromatogram, retention time (RT) 6.050 min was judged to be AlF-FAPI-74 based on the RT obtained from the AlF-FAPI-74 reference standard (c) and there is a time difference of approximately 0.3 min with the radioactivity detector. RT 6.519 min was judged to be FAPI-74 precursor based on prior analysis, and the remaining two peaks (RT 5.408 min and 5.878 min) were unknown impurity peaks. c The typical UV-chromatogram (λ = 264 nm) of AlF-FAPI-74 reference standard of 10 µg/mL (RT 6.039 min)

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