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Table 1 Examples of [18F]F− purification by QMA SPE cartridge

From: The aluminium-[18F]fluoride revolution: simple radiochemistry with a big impact for radiolabelled biomolecules

 

Cartridge

Wash

Eluent

References

1

Sep-Pak light QMA

–

0.9% NaCl (1 mL)

Jiang et al. (2021)

2

Sep-Pak Accell Plus QMA

Water (5 mL)

0.05 M NaOAc, pH 4.5 (300 µL)

Lütje et al. (2019)

3

Sep-Pak light QMA

Water

0.5 M NaOAc, pH 4.5 (500 µL)

Giglio et al. (2018)

4

Sep-Pak Accell Plus QMA

Purged to dryness

0.5 M NaHCO3 or NaNO3 or NaCl or NaOAc (600 µL)

Kersemans et al. (2018)

5

Sep-Pak Accell Plus QMA light

Water (6 mL)

0.9% NaCl (250 µL)

Tshibangu et al. (2020)

  1. Elution of [18F]F− from a QMA is invariably efficient (ca. 99% recovery) but the choice of eluent can modulate radioactive concentration. This was demonstrated by Kersemans et al. (2018) and may be considered as a parameter for optimisation when developing new [18F]AlF labelling protocols (Kersemans et al. 2018)