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Table 1 Radiosynthesis results of [18F]FMISO and [18F]PM-PBB3 by 18F-fluoroalkylation using precursor 6 and [18F]5

From: Automated radiosynthesis of two 18F-labeled tracers containing 3-fluoro-2-hydroxypropyl moiety, [18F]FMISO and [18F]PM-PBB3, via [18F]epifluorohydrin

  [18F]FMISO [18F]PM-PBB3
Cyclotron-produced [18F]F (GBq) 5.2 ± 0.20b 7.4 ± 0.20d
Radioactivity (GBq)a 0.83 ± 0.20b 0.79 ± 0.10d
Radiochemical yield (%)a 26 ± 7.5b(40c) 16 ± 3.2d(25 ± 6.0e)
Radiochemical purity (%)
 EOS 99 ± 0.50b 99 ± 0.50d
 3 h after EOS > 95c > 95d
Synthesis time (min) 75 ± 4.0b 78 ± 4.0d
Molar activity (GBq/µmol)a 110 ± 20c 330 ± 140d
  1. aAt the end of synthesis (EOS)
  2. bn = 8
  3. c the average result using 18F-fluorination in our routine radiosynthesis
  4. dn = 11
  5. ethe result using 18F-fluorination (n = 53) (Kawamura et al. 2021)