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Table 1 Radiosynthesis results of [18F]FMISO and [18F]PM-PBB3 by 18F-fluoroalkylation using precursor 6 and [18F]5

From: Automated radiosynthesis of two 18F-labeled tracers containing 3-fluoro-2-hydroxypropyl moiety, [18F]FMISO and [18F]PM-PBB3, via [18F]epifluorohydrin

 

[18F]FMISO

[18F]PM-PBB3

Cyclotron-produced [18F]F− (GBq)

5.2 ± 0.20b

7.4 ± 0.20d

Radioactivity (GBq)a

0.83 ± 0.20b

0.79 ± 0.10d

Radiochemical yield (%)a

26 ± 7.5b(40c)

16 ± 3.2d(25 ± 6.0e)

Radiochemical purity (%)

 EOS

99 ± 0.50b

99 ± 0.50d

 3 h after EOS

> 95c

> 95d

Synthesis time (min)

75 ± 4.0b

78 ± 4.0d

Molar activity (GBq/µmol)a

110 ± 20c

330 ± 140d

  1. aAt the end of synthesis (EOS)
  2. bn = 8
  3. c the average result using 18F-fluorination in our routine radiosynthesis
  4. dn = 11
  5. ethe result using 18F-fluorination (n = 53) (Kawamura et al. 2021)