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EJNMMI Radiopharmacy and Chemistry
Fig. 4 | EJNMMI Radiopharmacy and Chemistry

Fig. 4

From: Automated radiosynthesis of two 18F-labeled tracers containing 3-fluoro-2-hydroxypropyl moiety, [18F]FMISO and [18F]PM-PBB3, via [18F]epifluorohydrin

Fig. 4

Radiochemical yields of [18F]FMISO via [18F]5 in varied precursor dose (A) and reaction temperature (B). [18F]5 was distilled from the reaction vial and was transferred to the next reaction vial containing 6 (0.5, 1.0, 2.0 and 4.0 mg) and 1 mol/L NaOH (4.5, 9.0, 18 and 36 µL) in anhydrous DMF (0.25 mL) maintained at -15 °C. After 2 min of trapping of [18F]5, the reaction mixture was heated at 90, 110, 130, and 150 °C for 20 min to obtain [18F]FMISO

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