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Fig. 3 | EJNMMI Radiopharmacy and Chemistry

Fig. 3

From: Automated radiosynthesis of two 18F-labeled tracers containing 3-fluoro-2-hydroxypropyl moiety, [18F]FMISO and [18F]PM-PBB3, via [18F]epifluorohydrin

Fig. 3

Radiosynthesis of [18F]PM-PBB3 by 18F-fluorination with [18F]F and 18F-fluoroalkylation using [18F]epifluorohydrin ([18F]5). In this study, after the [18F]F solution was dried, a solution of 8 (3.5 mg) in o-dichlorobenzene (0.15 mL) was added to the reaction vial containing the dry [18F]F. The resulting [18F]5 was distilled from the reaction vial and was transferred to another reaction vial containing 7 (1 mg) and 1 mol/L NaOH (3.5 µL) in anhydrous DMF (0.25 mL) maintained at -15 °C. After 2 min of trapping of [18F]5, the reaction mixture was heated at 130 °C for 20 min to obtain [18F]PM-PBB3

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