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Table 4 Selected chelators for scandium and their complexation constants

From: Production of scandium radionuclides for theranostic applications: towards standardization of quality requirements

Acronym of the chelate

Name in the IUPAC nomenclature

Scheme of the molecule

Complexation constant with scandium

Only log KScL

Reference

DOTA

1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid

30.79

(Pniok et al. 2014)

AAZTA

1,4-bis(carboxymethyl)-6-[bis(carboxymethyl)]amino-6-methylperhydro-1,4-diazepine

27.69

(Nagy et al. 2017a)

NOTA

1,4,7-triaazacyclodeodecane-1,4,7-tetraacetic acid

18.5

(Huclier-Markai et al. 2011)

EDTA

Ethylene diamine tetra acetic acid

23.1

 Huclier-Markai et al., 2011

DTPA

Diethylene Triamine Pentaacetic Acid

27.43

(Pniok et al. 2014)

TETA

Tri-EthyleneTetra-Amine

18.0

 Huclier-Markai et al., 2011

DO3AP

1,4,7,10-TetraazacycloDOdecane-1,4,7-Tri-Acetic-10-methylPhosphonic acid

27.75

(Kerdjoudj et al. 2016)

DO3APPrA

10-{[(2-carboxyethyl)hydroxyPhosphoryl]methyl}-1,4,7,10-tetraazacycloDOdecane-1,4,7-Tri-Acetic acid

25.75

(Kerdjoudj et al. 2016)

DO3APABn

1,4,7,10-TetraazacycloDOdecane-4,7,10-Tri-Acetic-1-{methyl[(4-aminophenyl)methyl]Phosphinic acid}

25.51

(Kerdjoudj et al. 2016)

H4pypa

pyridinecarboxylate- based ligand

27

(Li et al. 2019b)

mpatcn

1,4-bis(methoxycarbonyl)-7-[(6-carboxypyridin-2-yl)methyl]-1,4,7-triazacyclononane

Constant not determined

(Vaughn et al. 2020a; Vaughn et al. 2020b)

picagaDUPA

prostate-specific membrane antigen (PSMA) - 2-[3-(1,3-dicarboxypropyl)ureido]pentanedioic acid (DUPA)

 

(Vaughn et al. 2020a; Vaughn et al., 2020b)

3,4,3 HOPO

hydroxypyridinone (HOPO)

25.16

(Carter et al. 2020)