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Table 4 Selected chelators for scandium and their complexation constants

From: Production of scandium radionuclides for theranostic applications: towards standardization of quality requirements

Acronym of the chelate Name in the IUPAC nomenclature Scheme of the molecule Complexation constant with scandium
Only log KScL
DOTA 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid 30.79 (Pniok et al. 2014)
AAZTA 1,4-bis(carboxymethyl)-6-[bis(carboxymethyl)]amino-6-methylperhydro-1,4-diazepine 27.69 (Nagy et al. 2017a)
NOTA 1,4,7-triaazacyclodeodecane-1,4,7-tetraacetic acid 18.5 (Huclier-Markai et al. 2011)
EDTA Ethylene diamine tetra acetic acid 23.1  Huclier-Markai et al., 2011
DTPA Diethylene Triamine Pentaacetic Acid 27.43 (Pniok et al. 2014)
TETA Tri-EthyleneTetra-Amine 18.0  Huclier-Markai et al., 2011
DO3AP 1,4,7,10-TetraazacycloDOdecane-1,4,7-Tri-Acetic-10-methylPhosphonic acid 27.75 (Kerdjoudj et al. 2016)
DO3APPrA 10-{[(2-carboxyethyl)hydroxyPhosphoryl]methyl}-1,4,7,10-tetraazacycloDOdecane-1,4,7-Tri-Acetic acid 25.75 (Kerdjoudj et al. 2016)
DO3APABn 1,4,7,10-TetraazacycloDOdecane-4,7,10-Tri-Acetic-1-{methyl[(4-aminophenyl)methyl]Phosphinic acid} 25.51 (Kerdjoudj et al. 2016)
H4pypa pyridinecarboxylate- based ligand 27 (Li et al. 2019b)
mpatcn 1,4-bis(methoxycarbonyl)-7-[(6-carboxypyridin-2-yl)methyl]-1,4,7-triazacyclononane Constant not determined (Vaughn et al. 2020a; Vaughn et al. 2020b)
picagaDUPA prostate-specific membrane antigen (PSMA) - 2-[3-(1,3-dicarboxypropyl)ureido]pentanedioic acid (DUPA)   (Vaughn et al. 2020a; Vaughn et al., 2020b)
3,4,3 HOPO hydroxypyridinone (HOPO) 25.16 (Carter et al. 2020)