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Table 2 Biodistribution of the MUC1-[18F] SFB and MUC1-FA-[18F] SFB hybrid peptide conjugates in tumor-bearing SCID mice

From: Fast Fluorine-18 labeling and preclinical evaluation of novel Mucin1 and its Folate hybrid peptide conjugate for targeting breast carcinoma

  MUC1-[18F]SFB MUC1-FA-[18F]SFB
60 min 60 min
blocked
60 min 60 min
blocked
Blood 0.35 ± 0.11 0.39 ± 0.15 0.67 ± 0.07 0.52 ± 0.05
Liver 0.85 ± 0.07 0.55 ± 0.17 3.20 ± 0.36 2.14 ± 0.13
Lung 1.39 ± 0.42 0.99 ± 0.22 2.96 ± 0.40 2.05 ± 0.49
Kidney 1.28 ± 0.03 1.20 ± 0.23 5.14 ± 0.53 1.86 ± 0.61
Intestine 0.21 ± 0.01 0.19 ± 0.08 4.36 ± 0.77 2.50 ± 0.65
Heart 0.38 ± 0.03 0.31 ± 0.07 1.98 ± 0.11 1.71 ± 0.12
Muscle 0.22 ± 0.13 0.24 ± 0.09 0.61 ± 0.05 0.25 ± 00.09
Bone 0.11 ± 0.01 0.15 ± 0.03 0.70 ± 0.14 0.30 ± 0.21
Spleen 1.07 ± 0.26 0.88 ± 0.11 2.95 ± 0.37 2.28 ± 0.71
Tumor 2.93 ± 0.12 1.61 ± 0.22 12.03 ± 0.57 1.37 ± 0.22
  1. The values are average of % injected dose/gram ± SD for n = 4