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EJNMMI Radiopharmacy and Chemistry
Scheme 3 | EJNMMI Radiopharmacy and Chemistry

Scheme 3

From: Design of PSMA ligands with modifications at the inhibitor part: an approach to reduce the salivary gland uptake of radiolabeled PSMA inhibitors?

Scheme 3

General, simplified synthetic routes for the preparation of L-2-aha (8), furyl (9), alkyne (10) and tetrazole (11) derivatives. Syntheses of the binding motifs of compounds 8 (L-2-aha), 9 (furyl) and 10 (alkyne) were conducted by a solid phase procedure, whereas binding motif 26 (tetrazole) was obtained by solution phase synthesis prior to coupling to compound 18. Detailed synthesis procedures are given in the supporting information

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