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Table 2 In vitro stability of 203Pb-labeled chelator complexes at 37 °C in human serum (n = 3)

From: Production, purification, and radiolabeling of the 203Pb/212Pb theranostic pair

203Pb-complex % stable Time point
8 h 24 h 48 h 72 h
[203Pb][Pb(TCMC)]2+ 98.0 ± 0.5% 98.1 ± 0.2% 98.2 ± 0.3% 97.2 ± 0.7%
[203Pb][Pb(DOTA)]2− 97.1 ± 0.7% 97.3 ± 0.6% 98.1 ± 0.2% 97.4 ± 0.5%
[203Pb][Pb(DOTA-1Py)] 97.4 ± 0.4% 97.7 ± 0.3% 98.1 ± 0.4% 97.5 ± 0.7%
[203Pb][Pb(DOTA-2Py)] 97.7 ± 0.1% 97.8 ± 0.1% 97.8 ± 0.9% 97.1 ± 0.2%
[203Pb][Pb(DOTA-3Py)]+ 98.4 ± 0.3% 98.0 ± 0.4% 98.4 ± 0.1% 97.7 ± 0.3%
Negative Control 1.2 ± 0.3% 1.4 ± 0.2% 1.4 ± 0.2% 1.5 ± 0.2%