Table 1 Description of the 9-step fully automated GMP production of [¹⁸F]Ga-rhPSMA-7/ -7.3

1

Solid phase extraction of [¹⁸F]Fluoride on QMA cartridge

1.0 min

2

Drying of QMA/[¹⁸F]Fluoride

1.5 min

3

Elution of [¹⁸F]Fluoride by [K⁺ ⊂ 2.2.2]OH⁻ in MeCN

0.5 min

4

isotopic exchange reaction on Ga-rhPSMA-7/ -7.3

5.0 min

5

Dilution with buffer

0.5 min

6

Extraction of precursor and product on HLB cartridge

1.0 min

7

Washing of HLB cartridge with buffer

2.0 min

8

Elution of precursor/product from HLB cartridge into product vial

0.5 min

9

Dilution of product solution with buffer

2.0 min

–

Sum of various intermediate steps

1.75 min

1–9

15.75 min