Table 1 Stability of [64Cu]Cu-DOTA-xPy (x = 2–4) and [64Cu]Cu-DOTA-xPy-MSH (x = 1–3) in phosphate buffer and human serum at 37 °C
From: Synthesis of DOTA-pyridine chelates for 64Cu coordination and radiolabeling of αMSH peptide
Radio-ligand | Phosphate buffer/% | Human serum/% | ||
|---|---|---|---|---|
1 h | 24 h | 1 h | 24 h | |
[64Cu]Cu-DOTA-2Py | 99.2 ± 0.1 | 99.1 ± 0.1 | 98.7 ± 0.3 | 94.6 ± 0.1 |
[64Cu]Cu-DOTA-3Py | 99.4 ± 0.3 | 99.2 ± 0.2 | 99.0 ± 0.1 | 96.1 ± 0.2 |
[64Cu]Cu-cyclen-4Py | 99.1 ± 0.1 | 99.0 ± 0.2 | 98.5 ± 0.1 | 97.2 ± 0.3 |
[64Cu]Cu-DOTA-1Py-αMSH | 99.3 ± 0.1 | 98.2 ± 0.2 | 98.4 ± 0.2 | 96.5 ± 0.3 |
[64Cu]Cu -DOTA-2Py-αMSH | 99.1 ± 0.04 | 98.6 ± 0.3 | 99.4 ± 0.2 | 98.3 ± 0.2 |
[64Cu]Cu -DOTA-3Py-αMSH | 99.2 ± 0.2 | 99.3 ± 0.2 | 98.1 ± 0.1 | 97.7 ± 0.2 |