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Table 3 Amounts of HEPES in different 68Ga-radiopharmaceuticals obtained from different institutes and analyzed by the HPLC method (n = the number of samples from different batches)

From: New sensitive method for HEPES quantification in 68Ga-radiopharmaceuticals

 [68Ga]Ga-DOTATOC
HEPES
(μg/mL)
Maximum amount in VInj (μg) aMaximum
VInj (mL)
Institute A (n = 3)21 ± 4171 ± 3510 ± 2
Institute B (n = 6)19 ± 8150 ± 6011 ± 1
Institute C____________
 [68Ga]Ga-PSMA-11
Institute A (n = 3)7 ± 1058 ± 8114 ± 3b
Institute B (n = 5)8 ± 764 ± 5416 ± 3b
Institute C____________
 [68Ga]Ga-NODAGA-Exendin
Institute A (n = 3)31 ± 1§291 ± 396 ± 1
Institute B (n = 3)36 ± 5§245 ± 126 ± 1
Institute C (n = 3)60 ± 8*482 ± 692 ± 1
  1. a When considering the recommended volume of injection of 8 mL. b When the amounts of HEPES were below LOQ, the total volume of the radiopharmaceutical (VT = 16 mL) was considered the maximum injected volume. §p < 0.05 when comparing the HEPES concentration present in different radiopharmaceuticals obtained from the same institute.* p < 0.05 when comparing the HEPES concentration present in the same radiopharmaceutical obtained in different institutes