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Table 1 Positioning of reagents and materials for the production of [18F]AlF-NOTA-octreotide on the Trasis AllinOne® radio-synthesizer platform

From: Automated GMP compliant production of [18F]AlF-NOTA-octreotide

Manifold position

Reagents or materials

1 vertical

Silicone tubing to [18O]H2O recovery vial

1 horizontal

Silicone tubing to pressure inlet

2

Silicone tubing to exhaust

3

Syringe of 3 ml (S1)

4

QMA eluent

5

QMA cartridge

6

H218O/18F inlet reservoir (S2)

7

Silicone tubing to QMA cartridge at position 5

8

[18F] NaF reservoir

9

Syringe of 1 mL (S3)

10

Silicone tubing to reactor

11

NOTA-octreotide precursor

12

HPCE grade water

13

Silicon tubing to dilution vial

14

EtOH

15

Syringe of 20 mL (S5)

16

Formulation solution

17

Silicone tubing to position 31

18 vertical

Silicone tubing to pressure inlet

18 horizontal

Silicone tubing to exhaust

31

Silicone tubing from position 17

33

C18 cartridge

34

Silicone tubing to C18 cartridge at position 33

35

Silicone tubing to waste

36 horizontal

Silicone tubing to dispensing cell