Table 1 Preliminary results of [18F]fluoride elution studies with various preconditioning and elution agents
Entry (n ≥ 2) | Cartridge | Cartridge preconditioning | Elution agenta | Elution speed | Fluoride recovery ± SD (%) | EEb ± SD (%) |
|---|---|---|---|---|---|---|
1 | QMA 10 mg | 0.5 M LiOTf, H2O | Cu(OTf)2(py)4 | slow | 57.8 ± 3.4 | 71.0 ± 4.4 |
2 | QMA 10 mg | 0.5 M LiOTf, H2O | Cu(OTf)2(py)4, LiOTf (1:1) | slow | 60.2 ± 5.9 | 73.5 ± 3.5 |
3 | QMA 10 mg | H2O | Cu(OTf)2(py)4 | slow | 55.8 ± 0.6 | 65.7 ± 0.4 |
4 | QMA 10 mg | H2O | Cu(OTf)2(py)4, LiOTf (1:1) | slow | 57.4 ± 2.2 | 68.6 ± 1.9 |
5 | QMA 130 mg | 0.5 M LiOTf, H2O | Cu(OTf)2(py)4 | slow | 47.1 ± 9.7 | 52.1 ± 11.3 |
6 | QMA 130 mg | 0.5 M LiOTf, H2O | Cu(OTf)2(py)4, LiOTf (1:1) | slow | 60.3 ± 2.7 | 67.3 ± 1.2 |
7 | QMA 130 mg | H2O | Cu(OTf)2(py)4 | slow | 40.1 ± 0.0 | 45.6 ± 0.6 |
8 | QMA 130 mg | H2O | Cu(OTf)2(py)4, LiOTf (1:1) | slow | 63.8 ± 4.2 | 73.6 ± 3.0 |
9 | QMA carb 46 mg | 0.5 M LiOTf, H2O | Cu(OTf)2(py)4 | slow | 41.8 ± 5.2 | 44.6 ± 5.6 |
10 | QMA carb 46 mg | 0.5 M LiOTf, H2O | Cu(OTf)2(py)4, LiOTf (1:1) | slow | 42.7 ± 4.4 | 46.1 ± 4.3 |
11 | QMA carb 46 mg | H2O | Cu(OTf)2(py)4 | slow | 25.3 ± 5.3 | 25.1 ± 3.0 |
12 | QMA carb 46 mg | H2O | Cu(OTf)2(py)4, LiOTf (1:1) | slow | 38.6 ± 2.1 | 42.7 ± 3.8 |
13 | QMA carb 46 mg | H2O | Cu(OTf)2(py)4 | fast | 19.9 ± 0.6 | 20.7 ± 0.8 |
14 | QMA carb 46 mg | 0.5 M Na2SO4, H2O | Cu(OTf)2(py)4 | slow | 0.6 ± 0.1 | 3.5 ± 0.4 |
15 | PS-HCO3 45 mg | 0.5 M LiOTf, H2O | Cu(OTf)2(py)4 | slow | 24.8 ± 14.6 | 37.2 ± 10.9 |
16 | PS-HCO3 45 mg | H2O | Cu(OTf)2(py)4 | slow | 31.6 ± 9.1 | 35.3 ± 10.6 |