Development and implementation of ISAR, a new synthesis platform for radiopharmaceutical production

EJNMMI Radiopharmacy and Chemistry

Table 3 Activity yield of the [¹³N]NH₃ Radiosyntheses

Entry	Beam	Activity Yield (GBq)	n
1	40 μA for 10 min	7.0 ± 2.0	9
2	40 μA for 10 min	8.9 ± 0.3	8
3^a	40 μA for 10 min	8.5 ± 0.7	3
4^b	30 μA for 6 min	2.5 ± 0.2	3
5^c	40 μA for 10 min	8.8 ± 0.1	3
6^d	40 μA for 30 min	23.7 ± 0.9	2

^a 1st run on chip; ^b traditional [¹³N]NH3 production using Devarda’s alloy (see: Scott 2012); ^c 2nd run on chip used in entry 3; ^d Product was eluted with 8 mL of 0.9% NaCl, Ph. Eur. to simplify handling and QC analysis of the concentrated dose